Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R126597-50mg | 50mg | In stock | $11.90 | |
R126597-250mg | 250mg | In stock | $42.90 | |
R126597-1g | 1g | In stock | $153.90 |
Selective COX-2 inhibitor. NSAID.
Synonyms | HMS2093E04 | MK966 | MK-966 | SB19518 | HMS1922H11 | KBioSS_000559 | STK635144 | SCHEMBL3050 | cMAP_000024 | KBio2_004913 | DB00533 | Ceoxx | NSC 758705 | 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2(5H)-furanone | CCG-40253 | HMS3713B07 | KBio3_002205 | MK 09 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Vioxx is a selective Cox-2 (cyclooxygenase-2) inhibitor that has anti-inflammatory properties.Selective COX-2 inhibitor. NSAID. Inhibits prostaglandin biosynthesis. Shows anti-inflammatory, analgesic, and antipyretic effects in vivo. Orally active. Blood- |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Cyclooxygenase-2 inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Rofecoxib is a COX-2 inhibitor with IC50 of 18 nM. |
ALogP | 2.3 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488179875 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179875 |
IUPAC Name | 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one |
INCHI | InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3 |
InChi Key | RZJQGNCSTQAWON-UHFFFAOYSA-N |
Canonical SMILES | CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3 |
Isomeric SMILES | CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3 |
WGK Germany | 3 |
RTECS | LU5135000 |
PubChem CID | 5090 |
Molecular Weight | 314.36 |
PubChem CID | 5090 |
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ChEMBL Ligand | CHEMBL122 |
Wikipedia | Rofecoxib |
DrugBank Ligand | DB00533 |
CAS Registry No. | 162011-90-7 |
ChEBI | CHEBI:8887 |
RCSB PDB Ligand | RCX |
PEP | rofecoxib |
DrugCentral Ligand | 2397 |
PubChem SID | 488179875 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
C1602032 | Certificate of Analysis | Aug 08, 2023 | R126597 |
D23211561 | Certificate of Analysis | Mar 16, 2023 | R126597 |
D23211566 | Certificate of Analysis | Mar 16, 2023 | R126597 |
D23211571 | Certificate of Analysis | Mar 16, 2023 | R126597 |
D23211587 | Certificate of Analysis | Mar 16, 2023 | R126597 |
Solubility | Soluble in water (<1 mg/ml at 25 °C), DMSO (63 mg/ml at 25 °C), methanol (slightly), DMF, and ethanol (<1 mg/ml at 25 °C). |
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Melt Point(°C) | 209 °C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RTECS | LU5135000 |
Merck Index | 8248 |