Potent and selective PDE4 inhibitor (IC50values are 0.2 to 4.3 nM for various splice variants of PDE4). Exhibits > 1000-fold selectivity for PDE4 over other PDE family members. Demonstrates effects on functioning of neutrophils, CD4+and CD8+T-cells, endot
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Phosphodiesterase 4 inhibitor
Note
10mg卖完停产，不再备货
Product Description
Roflumilast is a selective phosphodiesterase 4 (PDE4) (IC50 = 0.8 nM) inhibitor. Inhibition of PDE4 prevents the hydrolysis of phosphodiesters, which play a key role in signal transduction. This compound has anti-inflammatory properties and is particularly effective at reducing inflammation in lung tissue. A selective inhibitor of phosphodiesterase 4
1.Huang Z, Mancini JA. (2006) Phosphodiesterase 4 inhibitors for the treatment of asthma and COPD.. Curr Med Chem, 13 (27):(3253-62). [PMID:17168849]
2.Lebwohl MG, Papp KA, Stein Gold L, Gooderham MJ, Kircik LH, Draelos ZD, Kempers SE, Zirwas M, Smith K, Osborne DW et al.. (2020) Trial of Roflumilast Cream for Chronic Plaque Psoriasis.. N Engl J Med, 383 (3):(229-239). [PMID:32668113]
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J22111389