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Roscovitine (Seliciclib,CYC202) - ≥98%, high purity , Cyclin-dependent kinase 5 inhibitor, CAS No.186692-46-6, Cyclin-dependent kinase 5 inhibitor

  • Moligand™
  • ≥98%
Item Number
R125384
Grouped product items
SKUSizeAvailabilityPrice Qty
R125384-5mg
5mg
In stock
$28.90
R125384-25mg
25mg
In stock
$117.90
R125384-50mg
50mg
In stock
$195.90
R125384-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$260.90
R125384-250mg
250mg
In stock
$587.90
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Cdk inhibitor

View related series
cyclin dependent kinase 2 Inhibitor cyclin dependent kinase 9 Inhibitor

Basic Description

Synonymsroscovitine|Seliciclib|186692-46-6|R-Roscovitine|(R)-roscovitine|CYC202|CYC-202|CYC 202|Seliciclib [INN]|(R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol|2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine|Seliciclib (Ros
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InDry ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionCyclin-dependent kinase 5 inhibitor
Product Description

Roscovitine (Seliciclib, CYC202) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM. It shows little effect on CDK4/6. Phase 2.
A potent and selective inhibitor of cyclin-dependent kinases. Selective for Cdk1, Cdk2, and Cdk5.

Product Properties

ALogP3.2

Associated Targets

CDK9 Tchem Cyclin-dependent kinase 9 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
INCHI InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
InChi Key BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Canonical SMILES CCC(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3
Isomeric SMILES CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3
WGK Germany 3
PubChem CID 160355
Molecular Weight 354.45

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
G2220224Certificate of AnalysisJun 12, 2024 R125384
G2220199Certificate of AnalysisMay 15, 2024 R125384
G2220200Certificate of AnalysisMay 15, 2024 R125384
G2220206Certificate of AnalysisMay 15, 2024 R125384
G2220225Certificate of AnalysisMay 15, 2024 R125384

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 35.44, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 35.44, Max Conc. mM: 100
Melt Point(°C)106-107 °C

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

References

1. Fukushima T et al..  (2019)  Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium..  Cell Rep,  29  (12): (4144-4158.e7).  [PMID:31851939]

Solution Calculators

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