Click Here for 5% Off Your First Aladdin Purchase!
Call +1 (833) 552-7181 or Contact us Earn $25 in coupons on your first order with Aladdin!
Toggle Nav
My Cart
Search
Advanced Search
Menu
Sign In
྾
main product photo

Rosiglitazone - ≥98%, high purity , CAS No.122320-73-4, Agonist of FFA1 receptor;Agonist of Peroxisome proliferator-activated receptor-γ;Activator of TRPC5;Channel blocker of TRPM3

  • Moligand™
  • ≥98%
Item Number
R128083
Grouped product items
SKUSizeAvailabilityPrice Qty
R128083-250mg
250mg
In stock
$51.90
R128083-1g
1g
In stock
$157.90
R128083-5g
5g
In stock
$709.90
R128083-25g
25g
In stock
$3,193.90
Add to Wish List Compare
Bulk Order  SDS  DATASHEET

Selective PPARγ agonist

View related series
FFA1 receptor Agonist Peroxisome proliferator-activated receptor-γ Agonist TRPC5 Activator TRPM3 Channel blocker

Basic Description

Synonymsrosiglitazone|122320-73-4|Avandia|Rosiglizole|5-(4-(2-(Methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidine-2,4-dione|Brl-49653|Brl 49653|Rezult|Gaudil|Rosvel|BRL49653|TDZ 01|rosiglitazona|rosiglitazonum|Avandaryl|rosiglitazone (Avandia)|DTXSID7037131|C18
Specifications & Purity≥98%
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeACTIVATOR, AGONIST, CHANNEL BLOCKER
Mechanism of actionAgonist of FFA1 receptor;Agonist of Peroxisome proliferator-activated receptor-γ;Activator of TRPC5;Channel blocker of TRPM3
Product Description

A potent and selective PPARγ agonist.

Associated Targets

TRPM3 Tchem Transient receptor potential cation channel subfamily M member 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FFAR1 Tchem Free fatty acid receptor 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRPC5 Tchem Short transient receptor potential channel 5 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOB Tclin Amine oxidase [flavin-containing] B 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CISD1 Tchem CDGSH iron-sulfur domain-containing protein 1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PPARA Tclin Peroxisome proliferator-activated receptor alpha 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma 116 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
INCHI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
InChi Key YASAKCUCGLMORW-UHFFFAOYSA-N
Canonical SMILES CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
Isomeric SMILES CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
WGK Germany 3
PubChem CID 77999
Molecular Weight 357.43

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

19 results found

Lot NumberCertificate TypeDateItem
H2209699Certificate of AnalysisMay 08, 2024 R128083
H2209700Certificate of AnalysisMay 08, 2024 R128083
H2209703Certificate of AnalysisMay 08, 2024 R128083
G2416496Certificate of AnalysisApr 27, 2024 R128083
G2416593Certificate of AnalysisApr 27, 2024 R128083
G2416594Certificate of AnalysisApr 27, 2024 R128083
I2312628Certificate of AnalysisAug 31, 2023 R128083
I2312627Certificate of AnalysisAug 31, 2023 R128083
I2312626Certificate of AnalysisAug 31, 2023 R128083
I2312625Certificate of AnalysisAug 31, 2023 R128083
I2312624Certificate of AnalysisAug 31, 2023 R128083
I2312623Certificate of AnalysisAug 31, 2023 R128083
I2312622Certificate of AnalysisAug 31, 2023 R128083
F2427005Certificate of AnalysisAug 31, 2023 R128083
H2209702Certificate of AnalysisJun 20, 2022 R128083
E2308104Certificate of AnalysisJun 20, 2022 R128083
E2306015Certificate of AnalysisJun 20, 2022 R128083
G2222396Certificate of AnalysisJun 16, 2021 R128083
G2219227Certificate of AnalysisJun 16, 2021 R128083

more

Chemical and Physical Properties

SolubilitySoluble in DMSO (72 mg/ml at 25 °C), methanol, water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and DMF (~25 mg/ml).
Sensitivityheat sensitive
Melt Point(°C)156 °C

Safety and Hazards(GHS)

WGK Germany 3
Merck Index 8265

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. Rosiglitazone maleate - ≥99%, used for , CAS No. 155141-29-0, by Aladdin Scientific
    Rosiglitazone maleate, Peroxisome proliferator-activated receptor gamma agonist

    Starting at $136.90

  2. Rosiglitazone HCl - ≥99%, used for , CAS No. 302543-62-0, by Aladdin Scientific
    Rosiglitazone HCl

    Starting at $158.90

  3. Rosiglitazone (BRL 49653) - 10mM in DMSO, used for , CAS No. 122320-73-4(DMSO), by Aladdin Scientific
    Rosiglitazone (BRL 49653)

    Starting at $133.90

  4. Rosiglitazone (BRL-49653) maleate - 10mM in DMSO, used for , CAS No. 155141-29-0(DMSO), by Aladdin Scientific
    Rosiglitazone (BRL-49653) maleate

    Starting at $79.90

  5. 5-Hydroxy Rosiglitazone β-D-Glucuronide
    5-Hydroxy Rosiglitazone β-D-Glucuronide

    Starting at $527.90

  6. N-Desmethyl Rosiglitazone
    N-Desmethyl Rosiglitazone

    Starting at $178.90

  7. N-Desmethyl Rosiglitazone-d4
    N-Desmethyl Rosiglitazone-d4

    Starting at $285.90

  8. Rosiglitazone potassium salt
    Rosiglitazone potassium salt

    Starting at $57.90

References

1. Chen X, Yang L, Zhai SD.  (2012)  Risk of cardiovascular disease and all-cause mortality among diabetic patients prescribed rosiglitazone or pioglitazone: a meta-analysis of retrospective cohort studies..  Chin Med J,  125  (23): (4301-6).  [PMID:23217404]
2. Gantov M et al..  (2021)  Beige adipocytes contribute to breast cancer progression..  Oncol Rep,  45  (317-328).  [PMID:33416183]
3. Antoine A et al..  (2022)  Dysregulation of the Amniotic PPAR? Pathway by Phthalates: Modulation of the Anti-Inflammatory Activity of PPAR? in Human Fetal Membranes..  Life (Basel),  12  (4):   [PMID:35455039]
4. Chen X et al..  (2017)  Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs..  BMC Musculoskelet Disord,  18  (423).  [PMID:29073887]
5. Wu YX et al..  (2017)  Iguratimod prevents ovariectomy-induced bone loss and suppresses osteoclastogenesis via inhibition of peroxisome proliferator-activated receptor-?..  Mol Med Rep,  16  (6): (8200-8208).  [PMID:28983607]
6. Asimakopoulou A et al..  (2014)  Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver..  Biochim Biophys Acta,  1842  (10): (1513-24).  [PMID:25086218]
7. Pinkosky SL et al..  (2016)  Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis..  Nat Commun,  7  (13457).  [PMID:27892461]
8. Katoh-Fukui Y et al..  (2019)  Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones..  Bone,  120  (219-231).  [PMID:30389610]
9. Fu J et al..  (2021)  Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR-? to Inhibit the NF-?B/NLRP3 Inflammatory Axis in Spinal Cord Neurons..  PPAR Res,  2021  (6086265).  [PMID:34484316]

Solution Calculators

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.