Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R128083-250mg | 250mg | In stock | $51.90 | |
R128083-1g | 1g | In stock | $157.90 | |
R128083-5g | 5g | In stock | $709.90 | |
R128083-25g | 25g | In stock | $3,193.90 |
Selective PPARγ agonist
Synonyms | NSC-758698 | SCHEMBL14383595 | MFCD00137823 | 5-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)benzyl)-1,3-thiazolidine-2,4-dione | BCP0726000232 | Rosiglitazone- Bio-X | BCP03047 | HMS3884N08 | MFCD00000559 | Tox21_111434_1 | 5-((4-(2-Methyl-2-(pyridinylamino)e |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is antidiabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin.Selective PPARγ a |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ACTIVATOR, AGONIST, CHANNEL BLOCKER |
Mechanism of action | Agonist of FFA1 receptor;Agonist of Peroxisome proliferator-activated receptor-γ;Activator of TRPC5;Channel blocker of TRPM3 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | A potent and selective PPARγ agonist. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione |
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INCHI | InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23) |
InChi Key | YASAKCUCGLMORW-UHFFFAOYSA-N |
Canonical SMILES | CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3 |
Isomeric SMILES | CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3 |
WGK Germany | 3 |
PubChem CID | 77999 |
Molecular Weight | 357.43 |
PubChem CID | 77999 |
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ChEBI | CHEBI:50122 |
CAS Registry No. | 122320-73-4 |
Wikipedia | Rosiglitazone |
DrugBank Ligand | DB00412 |
BindingDB Ligand | 28681 |
ChEMBL Ligand | CHEMBL121 |
NURSA Ligand | 10.1621/M7WK877IB8 |
PEP | rosiglitazone |
DrugCentral Ligand | 2405 |
GPCRdb Ligand | rosiglitazone |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2209699 | Certificate of Analysis | May 08, 2024 | R128083 |
H2209700 | Certificate of Analysis | May 08, 2024 | R128083 |
H2209703 | Certificate of Analysis | May 08, 2024 | R128083 |
G2416496 | Certificate of Analysis | Apr 27, 2024 | R128083 |
G2416593 | Certificate of Analysis | Apr 27, 2024 | R128083 |
G2416594 | Certificate of Analysis | Apr 27, 2024 | R128083 |
I2312628 | Certificate of Analysis | Aug 31, 2023 | R128083 |
I2312627 | Certificate of Analysis | Aug 31, 2023 | R128083 |
I2312626 | Certificate of Analysis | Aug 31, 2023 | R128083 |
I2312625 | Certificate of Analysis | Aug 31, 2023 | R128083 |
I2312624 | Certificate of Analysis | Aug 31, 2023 | R128083 |
I2312623 | Certificate of Analysis | Aug 31, 2023 | R128083 |
I2312622 | Certificate of Analysis | Aug 31, 2023 | R128083 |
F2427005 | Certificate of Analysis | Aug 31, 2023 | R128083 |
H2209702 | Certificate of Analysis | Jun 20, 2022 | R128083 |
E2308104 | Certificate of Analysis | Jun 20, 2022 | R128083 |
E2306015 | Certificate of Analysis | Jun 20, 2022 | R128083 |
G2222396 | Certificate of Analysis | Jun 16, 2021 | R128083 |
G2219227 | Certificate of Analysis | Jun 16, 2021 | R128083 |
Solubility | Soluble in DMSO (72 mg/ml at 25 °C), methanol, water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and DMF (~25 mg/ml). |
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Sensitivity | heat sensitive |
Melt Point(°C) | 156 °C |
WGK Germany | 3 |
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Merck Index | 8265 |
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1. Ke Shenghui, Feng Yiwei, Luo Liying, Qin Wanzhao, Liu Huayu, Nie Jingchong, Liang Beijiang, Ma Hongjie, Xie Mao, Li Jingyu, Niu Zhijie, Li Guojian, Tang Anzhou, Xia Wei, He Guangyao. (2023) Isolation, identification, and induced differentiation of satellite cells from skeletal muscle of adult tree shrews. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, (1-18). [PMID:38127228] [10.1007/s11626-023-00836-5] |
2. Jiawen Ai, Weize Zhao, Quan Yu, Xiang Qian, Jianhua Zhou, Xinming Huo, Fei Tang. (2023) SR-Unet: A Super-Resolution Algorithm for Ion Trap Mass Spectrometers Based on the Deep Neural Network. ANALYTICAL CHEMISTRY, 95 (47): (17407–17415). [PMID:37963290] [10.1021/acs.analchem.3c04172] |
3. Zhang Shuai-nan, Liu Qi, Li Xu-zhao, Yang Wu-de, Zhou Ying. (2023) Cardioprotection of Eucommiae Folium: the extract and pharmaceutically active compounds attenuate hyperglycemia, mitochondrial dysfunction, calcium dyshomeostasis, insulin resistance, and oxidative stress in diabetic cardiomyopathy db/db mice. JOURNAL OF PHARMACY AND PHARMACOLOGY, 75 (12): (1509-1520). [PMID:37889854] [10.1093/jpp/rgad095] |
4. Yongju Ye, Weimei Zhou, Yuefang Ren, Jiali Lu, Aixue Chen, Ruiying Jin, Feilan Xuan. (2023) The ameliorating effects of Guizhi Fuling Wan combined with rosiglitazone in a rat ovarian model of polycystic ovary syndrome by the PI3K/AKT/NF-κB and Nrf2/HO-1 pathways. GYNECOLOGICAL ENDOCRINOLOGY, 39 (1): (2254848). [PMID:37706434] [10.1080/09513590.2023.2254848] |
5. Shi Sun, Yifang Wang, Jinhu Li, Ailing Wu, Yan Xie, Zhao Wang, Xinjie Zhao, Dandan Wang, Xiaolong Wu, Xinguang Liu. (2023) Network Pharmacology-Based Approach to Investigate the Active Ingredients and Therapeutic Mechanisms of Jingu Tongxiao Pill against Osteoarthritis. ACS Omega, [PMID:37663478] [10.1021/acsomega.3c04724] |
6. Jianv Wang, Jing Jia, Qingqing He, Yang Xu, Hongye Liao, Xia Xiong, Li Liu, Changzhen Sun. (2023) A novel multifunctional mitochondrion-targeting NIR fluorophore probe inhibits tumour proliferation and metastasis through the PPARγ/ROS/β-catenin pathway. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 258 (115435). [PMID:37327679] [10.1016/j.ejmech.2023.115435] |
7. Zhuling Shao, Yingying Tian, Shan Liu, Xiao Chu, Wenjun Mao. (2023) Anti-Diabetic Activity of a Novel Exopolysaccharide Produced by the Mangrove Endophytic Fungus Penicillium janthinellum N29. Marine Drugs, 21 (5): (270). [PMID:37233464] [10.3390/md21050270] |
8. Yin Zhuang, Xiangying Sun, Siting Deng, Ya Wen, Qiujin Xu, Quanquan Guan. (2023) In vivo effects of low dose prenatal bisphenol A exposure on adiposity in male and female ICR offspring. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 257 (114946). [PMID:37105096] [10.1016/j.ecoenv.2023.114946] |
9. Zixian He, Zhiwei Liu, Haihuan Xie, Pengjie Luo, Xiangmei Li. (2023) An Ultrasensitive Lateral Flow Immunoassay Based on Metal-Organic Framework-Decorated Polydopamine for Multiple Sulfonylureas Adulteration in Functional Foods. Foods, 12 (3): (539). [PMID:36766067] [10.3390/foods12030539] |
10. Jingyi Hu, Yiheng Tong, Zhaofeng Shen, Yanan Li, Cheng Cheng, Ryan Au, Feng Xu, Yajun Liu, Lei Zhu, Hong Shen. (2022) Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling. BIOMEDICINE & PHARMACOTHERAPY, 154 (113571). [PMID:36007273] [10.1016/j.biopha.2022.113571] |
11. Miaomiao Chi, Kunming Qin, Lei Cao, Min Zhang, Yingying Su, Xun Gao. (2022) Surface Functionalized Magnetic Nanoparticles as a Selective Sorbent for Affinity Fishing of PPAR-γ Ligands from Choerospondias axillaris. MOLECULES, 27 (10): (3127). [PMID:35630609] [10.3390/molecules27103127] |
12. Haihuan Xie, Yingying Li, Jin Wang, Yi Lei, Anastasios Koidis, Xiangmei Li, Xing Shen, Zhenlin Xu, Hongtao Lei. (2022) Broad-specific immunochromatography for simultaneous detection of various sulfonylureas in adulterated multi-herbal tea. FOOD CHEMISTRY, 370 (131055). [PMID:34536782] [10.1016/j.foodchem.2021.131055] |
13. Lili Tan, Jie Lu, Limin Liu, Lu Li. (2021) Fatty acid binding protein 3 deficiency limits atherosclerosis development via macrophage foam cell formation inhibition. EXPERIMENTAL CELL RESEARCH, 407 (112768). [PMID:34370993] [10.1016/j.yexcr.2021.112768] |
14. Mei Wang, Shan-Quan Chang, Yu-Shan Tian, Ge-Qiang Zhang, Jin Qi. (2020) Zengye Decoction Ameliorates Insulin Resistance by Promoting Glucose Uptake. REJUVENATION RESEARCH, 23 (5): (367-376). [PMID:31941423] [10.1089/rej.2019.2228] |
15. Tianlei Sun, Cheryl H. T. Kwong, Cheng Gao, Jianwen Wei, Ludan Yue, Jianxiang Zhang, Richard Dequan Ye, Ruibing Wang. (2020) Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine. Theranostics, 10 (22): ( 10106–10119). [PMID:32929337] [10.7150/thno.48448] |
16. Zhishen Xie, Jianping Zhao, Hui Wang, Yali Jiang, Qiaoling Yang, Yu Fu, Huahui Zeng, Christian Hölscher, Jiangyan Xu, Zhenqiang Zhang. (2020) Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ. BIOMEDICINE & PHARMACOTHERAPY, 124 (109886). [PMID:32000045] [10.1016/j.biopha.2020.109886] |
17. Tan Jianxin, Wang Yajun, Wang Siliang, Wu Simeng, Yuan Zhe, Zhu Xike. (2019) Label-free quantitative proteomics identifies transforming growth factor β1 (TGF-β1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells. Cell and Bioscience, 9 (1): (1-15). [PMID:31249661] [10.1186/s13578-019-0311-1] |
18. Jianxin Tan, Yajun Wang, Siliang Wang, Nannan Zhang, Simeng Wu, Zhe Yuan, Xike Zhu. (2017) Untargeted metabolomics analysis of adipogenic transformation in OP9-DL1 cells using liquid chromatography-mass spectrometry: Implications for thymic adipogenesis. CELL BIOLOGY INTERNATIONAL, 41 (4): (447-456). [PMID:28185342] [10.1002/cbin.10740] |
19. Wei Guo,Jian Han,Shengmin Wu,Xiongjie Shi,Qiangwei Wang,Bingsheng Zhou. (2019-12-06) Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Affects Lipid Metabolism in Zebrafish Larvae via DNA Methylation Modification.. Environmental science & technology, 54 ((1)): (355-363). [PMID:31804803] |
1. Chen X, Yang L, Zhai SD. (2012) Risk of cardiovascular disease and all-cause mortality among diabetic patients prescribed rosiglitazone or pioglitazone: a meta-analysis of retrospective cohort studies.. Chin Med J, 125 (23): (4301-6). [PMID:23217404] [10.1021/op500134e] |
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5. Wu YX et al.. (2017) Iguratimod prevents ovariectomy-induced bone loss and suppresses osteoclastogenesis via inhibition of peroxisome proliferator-activated receptor-?.. Mol Med Rep, 16 (6): (8200-8208). [PMID:28983607] |
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9. Fu J et al.. (2021) Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR-? to Inhibit the NF-?B/NLRP3 Inflammatory Axis in Spinal Cord Neurons.. PPAR Res, 2021 (6086265). [PMID:34484316] |
10. Ke Shenghui, Feng Yiwei, Luo Liying, Qin Wanzhao, Liu Huayu, Nie Jingchong, Liang Beijiang, Ma Hongjie, Xie Mao, Li Jingyu, Niu Zhijie, Li Guojian, Tang Anzhou, Xia Wei, He Guangyao. (2023) Isolation, identification, and induced differentiation of satellite cells from skeletal muscle of adult tree shrews. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, (1-18). [PMID:38127228] [10.1007/s11626-023-00836-5] |
11. Jiawen Ai, Weize Zhao, Quan Yu, Xiang Qian, Jianhua Zhou, Xinming Huo, Fei Tang. (2023) SR-Unet: A Super-Resolution Algorithm for Ion Trap Mass Spectrometers Based on the Deep Neural Network. ANALYTICAL CHEMISTRY, 95 (47): (17407–17415). [PMID:37963290] [10.1021/acs.analchem.3c04172] |
12. Zhang Shuai-nan, Liu Qi, Li Xu-zhao, Yang Wu-de, Zhou Ying. (2023) Cardioprotection of Eucommiae Folium: the extract and pharmaceutically active compounds attenuate hyperglycemia, mitochondrial dysfunction, calcium dyshomeostasis, insulin resistance, and oxidative stress in diabetic cardiomyopathy db/db mice. JOURNAL OF PHARMACY AND PHARMACOLOGY, 75 (12): (1509-1520). [PMID:37889854] [10.1093/jpp/rgad095] |
13. Yongju Ye, Weimei Zhou, Yuefang Ren, Jiali Lu, Aixue Chen, Ruiying Jin, Feilan Xuan. (2023) The ameliorating effects of Guizhi Fuling Wan combined with rosiglitazone in a rat ovarian model of polycystic ovary syndrome by the PI3K/AKT/NF-κB and Nrf2/HO-1 pathways. GYNECOLOGICAL ENDOCRINOLOGY, 39 (1): (2254848). [PMID:37706434] [10.1080/09513590.2023.2254848] |
14. Shi Sun, Yifang Wang, Jinhu Li, Ailing Wu, Yan Xie, Zhao Wang, Xinjie Zhao, Dandan Wang, Xiaolong Wu, Xinguang Liu. (2023) Network Pharmacology-Based Approach to Investigate the Active Ingredients and Therapeutic Mechanisms of Jingu Tongxiao Pill against Osteoarthritis. ACS Omega, [PMID:37663478] [10.1021/acsomega.3c04724] |
15. Jianv Wang, Jing Jia, Qingqing He, Yang Xu, Hongye Liao, Xia Xiong, Li Liu, Changzhen Sun. (2023) A novel multifunctional mitochondrion-targeting NIR fluorophore probe inhibits tumour proliferation and metastasis through the PPARγ/ROS/β-catenin pathway. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 258 (115435). [PMID:37327679] [10.1016/j.ejmech.2023.115435] |
16. Zhuling Shao, Yingying Tian, Shan Liu, Xiao Chu, Wenjun Mao. (2023) Anti-Diabetic Activity of a Novel Exopolysaccharide Produced by the Mangrove Endophytic Fungus Penicillium janthinellum N29. Marine Drugs, 21 (5): (270). [PMID:37233464] [10.3390/md21050270] |
17. Yin Zhuang, Xiangying Sun, Siting Deng, Ya Wen, Qiujin Xu, Quanquan Guan. (2023) In vivo effects of low dose prenatal bisphenol A exposure on adiposity in male and female ICR offspring. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 257 (114946). [PMID:37105096] [10.1016/j.ecoenv.2023.114946] |
18. Zixian He, Zhiwei Liu, Haihuan Xie, Pengjie Luo, Xiangmei Li. (2023) An Ultrasensitive Lateral Flow Immunoassay Based on Metal-Organic Framework-Decorated Polydopamine for Multiple Sulfonylureas Adulteration in Functional Foods. Foods, 12 (3): (539). [PMID:36766067] [10.3390/foods12030539] |
19. Jingyi Hu, Yiheng Tong, Zhaofeng Shen, Yanan Li, Cheng Cheng, Ryan Au, Feng Xu, Yajun Liu, Lei Zhu, Hong Shen. (2022) Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling. BIOMEDICINE & PHARMACOTHERAPY, 154 (113571). [PMID:36007273] [10.1016/j.biopha.2022.113571] |
20. Miaomiao Chi, Kunming Qin, Lei Cao, Min Zhang, Yingying Su, Xun Gao. (2022) Surface Functionalized Magnetic Nanoparticles as a Selective Sorbent for Affinity Fishing of PPAR-γ Ligands from Choerospondias axillaris. MOLECULES, 27 (10): (3127). [PMID:35630609] [10.3390/molecules27103127] |
21. Haihuan Xie, Yingying Li, Jin Wang, Yi Lei, Anastasios Koidis, Xiangmei Li, Xing Shen, Zhenlin Xu, Hongtao Lei. (2022) Broad-specific immunochromatography for simultaneous detection of various sulfonylureas in adulterated multi-herbal tea. FOOD CHEMISTRY, 370 (131055). [PMID:34536782] [10.1016/j.foodchem.2021.131055] |
22. Lili Tan, Jie Lu, Limin Liu, Lu Li. (2021) Fatty acid binding protein 3 deficiency limits atherosclerosis development via macrophage foam cell formation inhibition. EXPERIMENTAL CELL RESEARCH, 407 (112768). [PMID:34370993] [10.1016/j.yexcr.2021.112768] |
23. Mei Wang, Shan-Quan Chang, Yu-Shan Tian, Ge-Qiang Zhang, Jin Qi. (2020) Zengye Decoction Ameliorates Insulin Resistance by Promoting Glucose Uptake. REJUVENATION RESEARCH, 23 (5): (367-376). [PMID:31941423] [10.1089/rej.2019.2228] |
24. Tianlei Sun, Cheryl H. T. Kwong, Cheng Gao, Jianwen Wei, Ludan Yue, Jianxiang Zhang, Richard Dequan Ye, Ruibing Wang. (2020) Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine. Theranostics, 10 (22): ( 10106–10119). [PMID:32929337] [10.7150/thno.48448] |
25. Zhishen Xie, Jianping Zhao, Hui Wang, Yali Jiang, Qiaoling Yang, Yu Fu, Huahui Zeng, Christian Hölscher, Jiangyan Xu, Zhenqiang Zhang. (2020) Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ. BIOMEDICINE & PHARMACOTHERAPY, 124 (109886). [PMID:32000045] [10.1016/j.biopha.2020.109886] |
26. Tan Jianxin, Wang Yajun, Wang Siliang, Wu Simeng, Yuan Zhe, Zhu Xike. (2019) Label-free quantitative proteomics identifies transforming growth factor β1 (TGF-β1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells. Cell and Bioscience, 9 (1): (1-15). [PMID:31249661] [10.1186/s13578-019-0311-1] |
27. Jianxin Tan, Yajun Wang, Siliang Wang, Nannan Zhang, Simeng Wu, Zhe Yuan, Xike Zhu. (2017) Untargeted metabolomics analysis of adipogenic transformation in OP9-DL1 cells using liquid chromatography-mass spectrometry: Implications for thymic adipogenesis. CELL BIOLOGY INTERNATIONAL, 41 (4): (447-456). [PMID:28185342] [10.1002/cbin.10740] |
28. Wei Guo,Jian Han,Shengmin Wu,Xiongjie Shi,Qiangwei Wang,Bingsheng Zhou. (2019-12-06) Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Affects Lipid Metabolism in Zebrafish Larvae via DNA Methylation Modification.. Environmental science & technology, 54 ((1)): (355-363). [PMID:31804803] |