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Rosiglitazone maleate - ≥99%, high purity , Peroxisome proliferator-activated receptor gamma agonist, CAS No.155141-29-0, Peroxisome proliferator-activated receptor gamma agonist

≥99%

CAS#: 155141-29-0
Formula: C₁₈H₁₉N₃O₃S.C₄H₄O₄
Molecular Weight: 473.5
PubChem CID: 5281055

Item Number

R129756

Grouped product items
SKU	Size	Availability	Price
R129756-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$136.90
R129756-100mg	100mg	In stock	$492.90
R129756-500mg	500mg	In stock	$2,216.90
R129756-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$3,989.90
R129756-5g	5g	In stock	$17,950.90
R129756-10g	10g	In stock	$32,311.90

Potent, selective PPARγ agonist. Maleate salt.

Basic Description

Synonyms	Rosiglitazone maleate\|155141-29-0\|Avandia\|Rosiglitazone XR\|Rosiglitazone (maleate)\|Rosiglitazone Maleate [USAN]\|BRL-49653C\|BRL 49653C\|Rosiglitzazone maleate\|BRL-49653-C\|NSC-717764\|UNII-KX2339DP44\|5-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidi
Specifications & Purity	≥99%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	AGONIST
Mechanism of action	Peroxisome proliferator-activated receptor gamma agonist

Names and Identifiers

IUPAC Name	(Z)-but-2-enedioic acid;5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
INCHI	InChI=1S/C18H19N3O3S.C4H4O4/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;5-3(6)1-2-4(7)8/h2-9,15H,10-12H2,1H3,(H,20,22,23);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key	SUFUKZSWUHZXAV-BTJKTKAUSA-N
Canonical SMILES	CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=CC(=O)O)C(=O)O
Isomeric SMILES	CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=C\C(=O)O)\C(=O)O
PubChem CID	5281055
Molecular Weight	473.5

Certificates

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6 results found

Lot Number	Certificate Type	Date	Item
E2217131	Certificate of Analysis	May 10, 2024	R129756
F2220022	Certificate of Analysis	Apr 02, 2024	R129756
F2220021	Certificate of Analysis	Apr 02, 2024	R129756
F2220020	Certificate of Analysis	Apr 02, 2024	R129756
E2217143	Certificate of Analysis	Mar 14, 2024	R129756
E2217152	Certificate of Analysis	Mar 14, 2024	R129756

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS09, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

References

1. Kraakman MJ et al.. (2018) PPAR? deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.. J Clin Invest, 128 (6): (2600-2612). [PMID:29589839]
2. Aaron N et al.. (2021) Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells.. Elife, 10 [PMID:34155972]
3. Chan M et al.. (2019) Identification of a natural beige adipose depot in mice.. J Biol Chem, 294 (17): (6751-6761). [PMID:30824545]
4. Liu L et al.. (2020) PPAR? Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment.. Diabetes, 69 (8): (1793-1803). [PMID:32409492]

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