Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R105076-1g | 1g | In stock | $58.90 | |
R105076-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $105.90 | |
R105076-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $379.90 |
Mitochondrial electron transport chain complex I inhibitor. Potent NADH oxidation inhibitor.
Synonyms | C23H22O6 | EINECS 201-501-9 | Spectrum4_001638 | Derris resins | Liquid Derris | (1S,6R,13S)-16,17-dimethoxy-6-prop-1-en-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one | (2R,6aS,12aS)-8,9-Dimethoxy-2-(pr |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | Mitochondrial electron transport chain complex I inhibitor (IC 50 values are 1.7 - 2.2 µM). Potent NADH oxidation inhibitor (IC 50 = 3.4 nM). Suppresses microtubule assembly. Induces BRL cell apoptosis. Shows antiproliferative effects. |
Storage Temp | Argon charged |
Shipped In | Normal |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (1S,6R,13S)-16,17-dimethoxy-6-prop-1-en-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one |
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INCHI | InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1 |
InChi Key | JUVIOZPCNVVQFO-HBGVWJBISA-N |
Canonical SMILES | CC(=C)C1CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4C3=O)OC)OC |
Isomeric SMILES | CC(=C)[C@H]1CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC |
WGK Germany | 3 |
PubChem CID | 6758 |
UN Number | 2588 |
Packing Group | I |
Molecular Weight | 394.42 |
Beilstein | 6773081 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2409119 | Certificate of Analysis | Jul 23, 2024 | R105076 |
G2409122 | Certificate of Analysis | Jul 22, 2024 | R105076 |
A2405059 | Certificate of Analysis | Oct 24, 2023 | R105076 |
A2423058 | Certificate of Analysis | Oct 24, 2023 | R105076 |
I2208493 | Certificate of Analysis | Oct 24, 2023 | R105076 |
I2208494 | Certificate of Analysis | Oct 24, 2023 | R105076 |
I2208495 | Certificate of Analysis | Oct 24, 2023 | R105076 |
Sensitivity | Light & Air sensitive |
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Boil Point(°C) | 210-220°C |
Melt Point(°C) | 159-164°C |
Pictogram(s) | GHS06, GHS09 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P501:Dispose of contents/container to ... |
WGK Germany | 3 |
Class | 6.1 |
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