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Rottlerin - ≥95%, high purity , CAS No.82-08-6, Activator of K v11.1;Inhibitor of protein kinase C delta

Moligand™
≥95%

CAS#: 82-08-6
Formula: C₃₀H₂₈O₈
Molecular Weight: 516.55
PubChem CID: 5281847

Item Number

R275595

Grouped product items
SKU	Size	Availability	Price
R275595-5mg	5mg	In stock	$39.90
R275595-10mg	10mg	In stock	$64.90
R275595-25mg	25mg	In stock	$140.90
R275595-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$253.90
R275595-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$456.90

Kinase inhibitor

View related series

Kv11.1 Activator protein kinase C delta Inhibitor

Basic Description

Synonyms	rottlerin\|Mallotoxin\|82-08-6\|Kamalin\|NSC 56346\|NSC 94525\|E29LP3ZMUH\|(E)-1-(6-((3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl)-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one\|CHEMBL34241\|CHEBI:8899\|NSC56346\|NSC94525\|NSC-56346\|NSC
Specifications & Purity	≥95%
Storage Temp	Store at -20°C,Argon charged,Desiccated
Shipped In	Dry ice
Grade	Moligand™
Action Type	ACTIVATOR, INHIBITOR
Mechanism of action	Activator of K v11.1;Inhibitor of protein kinase C delta
Product Description	Product Description： A cell-permeable and reversible inhibitor of protein kinase C δ (PKCδ, IC50 = 3-6 µM) and PKCΘ isozymes. Also inhibits PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCξ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).

Associated Targets

PRKCD Tclin Protein kinase C delta type 0 Activities

Discover Target: PRKCD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 1 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one
INCHI	InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
InChi Key	DEZFNHCVIZBHBI-ZHACJKMWSA-N
Canonical SMILES	CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C(=C3C(=C2O)C=CC(O3)(C)C)C(=O)C=CC4=CC=CC=C4)O)O
Isomeric SMILES	CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C(=C3C(=C2O)C=CC(O3)(C)C)C(=O)/C=C/C4=CC=CC=C4)O)O
PubChem CID	5281847
Molecular Weight	516.55

PubChem CID

ChEMBL Ligand

BindingDB Ligand

Wikipedia

CAS Registry No.

ChEBI

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7 results found

Lot Number	Certificate Type	Date	Item
E2230330	Certificate of Analysis	Dec 20, 2023	R275595
D2227004	Certificate of Analysis	Feb 09, 2023	R275595
C2214187	Certificate of Analysis	Dec 15, 2022	R275595
C2214188	Certificate of Analysis	Dec 15, 2022	R275595
C2214189	Certificate of Analysis	Dec 15, 2022	R275595
C2212282	Certificate of Analysis	Dec 15, 2022	R275595
C2212432	Certificate of Analysis	Dec 15, 2022	R275595

References

1. Gschwendt M, Müller HJ, Kielbassa K, Zang R, Kittstein W, Rincke G, Marks F. (1994) Rottlerin, a novel protein kinase inhibitor.. Biochem Biophys Res Commun, 199 (1): (93-8). [PMID:8123051]
2. Hegazy AM et al.. (2016) Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance.. J Biol Chem, 291 (41): (21496-21509). [PMID:27519418]

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