Rottlerin - ≥95%, high purity , CAS No.82-08-6, Activator of K v11.1;Inhibitor of protein kinase C delta

Item Number

R275595

• Synonyms: 1-[6-(3-Acetyl-2,4,6-trihydroxy-5-methyl-benzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-3-phenyl-propenone | BMK1-F10 | Lopac0_001052 | EINECS 201-395-4 | F88130 | NSC 94525Mallotoxin | R5648 (Rottlerin) | IDI1_002135 | NCGC00025228-11 | BiomolKI_000
• Specifications & Purity: Moligand™, ≥95%
• Biochemical and Physiological Mechanisms: Originally reported to inhibit PKC isoforms, especially PKCδ and CAM-KIII. Also inhibits MAPKAP-K2 and PRAK (IC 50 values are 5.4 and 1.9 μM, respectively), CHK2, PLK1, PIM3 and SRPK1. Cell permeable: yes Product does not compete with ATP. Primary Target
• Storage Temp: Store at -20°C,Argon charged,Desiccated
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ACTIVATOR, INHIBITOR
• Mechanism of action: Activator of K v11.1;Inhibitor of protein kinase C delta
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Product Description：

A cell-permeable and reversible inhibitor of protein kinase C δ (PKCδ, IC50 = 3-6 µM) and PKCΘ isozymes. Also inhibits PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCξ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).