Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R129251-1g | 1g | In stock | $64.90 | |
R129251-5g | 5g | In stock | $116.90 | |
R129251-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $526.90 | |
R129251-100g | 100g | In stock | $1,895.90 |
Bacterial protein synthesis inhibitor, macrolide antibiotic
Synonyms | BRD-K38684403-001-05-4 | DTXSID8041117 | GS-6117 | SCHEMBL145394 | NSC-758443 | ROXITHROMYCIN [INN] | Tox21_110697 | (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[( |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Roxithromycin is an antibiotic with an immunomodulatory effect and a wide antibacterial spectrum against oral pathogens. Roxithromycin has also been shown to increase neutrophil apoptosis.Bacterial protein synthesis inhibitor, macrolide antibiotic. Binds |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of motilin receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Used to block bacterial protein synthesis. Clinically, used to treat respiratory tract, urinary and soft tissue infections. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one |
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INCHI | InChI=1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+/t22-,23-,24+,25+,26-,27+,28+,29-,30+,32-,33+,34-,35+,36-,38+,39-,40-,41-/m1/s1 |
InChi Key | RXZBMPWDPOLZGW-XMRMVWPWSA-N |
Canonical SMILES | CCC1C(C(C(C(=NOCOCCOC)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O |
Isomeric SMILES | CC[C@@H]1[C@@]([C@@H]([C@H](/C(=N/OCOCCOC)/[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O |
WGK Germany | 3 |
RTECS | KF4990000 |
PubChem CID | 6915744 |
Molecular Weight | 837.05 |
PubChem CID | 6915744 |
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ChEMBL Ligand | CHEMBL1214185 |
Wikipedia | Roxithromycin |
CAS Registry No. | 80214-83-1 |
DrugBank Ligand | DB00778 |
RCSB PDB Ligand | ROX |
DrugCentral Ligand | 2410 |
Antibiotic DB | 1998 |
GPCRdb Ligand | roxithromycin |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2428009 | Certificate of Analysis | Jul 03, 2024 | R129251 |
A2419065 | Certificate of Analysis | Jan 26, 2024 | R129251 |
A2429384 | Certificate of Analysis | Sep 14, 2023 | R129251 |
K21171181 | Certificate of Analysis | Sep 14, 2023 | R129251 |
K21171185 | Certificate of Analysis | Sep 14, 2023 | R129251 |
K21171186 | Certificate of Analysis | Sep 14, 2023 | R129251 |
K2025152 | Certificate of Analysis | Sep 16, 2022 | R129251 |
F1822060 | Certificate of Analysis | Feb 15, 2022 | R129251 |
C2406029 | Certificate of Analysis | Oct 11, 2021 | R129251 |
D2306094 | Certificate of Analysis | Oct 11, 2021 | R129251 |
G2314170 | Certificate of Analysis | Oct 11, 2021 | R129251 |
G2314176 | Certificate of Analysis | Oct 11, 2021 | R129251 |
Solubility | DMSO 167 mg/mL Water Ethanol 167 mg/mL |
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Flash Point(°F) | >110℃(230°F) |
Flash Point(°C) | >110℃(230°F) |
Melt Point(°C) | 111-118°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RTECS | KF4990000 |
1. Jun Yao. (2024) A multiple signal amplification photoelectrochemical biosensor based on biotin-avidin system for kanamycin sensing in fish and milk via synergism of g-C3N4 and Ru@SiO2. ANALYTICA CHIMICA ACTA, 1288 (342141). [PMID:38220276] [10.1016/j.aca.2023.342141] |
2. Xiaoyu Zhang, Peiran Meng, Wei Wang, Xiwen Li, Zuan Yang, Shaokai Du, Yue Sun. (2023) Simultaneous Electrochemical Determination of Erythromycin and Hemoglobin by Flexible Carbon Cloth Modified with ZnO Nanorod Arrays and Au Nanoparticles by Differential Pulse Voltammetry (DPV). ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2023.2292664] |
3. Qing Fang, Qin Liu, Zongli Xie, Matthew R. Hill, Kaisong Zhang. (2024) Ultra-thin PTMSP nanocomposite membranes incorporated with functionalized MoS2 nanosheets for pharmaceutical concentration and solvent recovery. SEPARATION AND PURIFICATION TECHNOLOGY, 330 (125296). [PMID:16479015] [10.1016/j.seppur.2023.125296] |
4. Jutao Hu, Xiaoyu Su, Lei Yuan, Kaiyi Zheng, Xiaobo Zou, Zongbao Sun, Xuechao Xu, Wen Zhang. (2023) Competitive immunoassay using enzyme-regulated Fe3O4@COF/Fe3+ fluorescence probe for natural chloramphenicol detection. ANALYTICA CHIMICA ACTA, 1277 (341680). [PMID:37604605] [10.1016/j.aca.2023.341680] |
5. Zhiwen Li, Zhilin Zhou, Jianghua Wang, Tingxian Tao, Yingqiang Fu. (2023) Aggregation-induced emission enhancement N, S-CQDs for selective detection of CIP in the environment. NANOTECHNOLOGY, 34 (39): (395503). [PMID:37343538] [10.1088/1361-6528/ace05a] |
6. Weifu Geng, Yan Feng, Yu Chen, Xin Zhang, Haoyi Zhang, Fanfan Yang, Xiuzhong Wang. (2023) Interactions of Amino Group Functionalized Tetraphenylvinyl and DNA: A Label-Free “On-Off-On” Fluorescent Aptamer Sensor toward Ampicillin. Biosensors-Basel, 13 (5): (504). [PMID:37232865] [10.3390/bios13050504] |
7. Shuying Mao, Wei Jin, Sisi Fu, Keanqi Liu, Feng Xu, Linlin Wu, Yexin Xu, Huizhu Yang, Huafang Liu, Guangji Wang, Yan Liang. (2023) Strategies for mapping protein hydrolysate profiles and pharmacokinetics based on non-targeted proteomics combining skyline-aided quantitative techniques. ANALYTICA CHIMICA ACTA, 1265 (341272). [PMID:37230566] [10.1016/j.aca.2023.341272] |
8. Junyang Pan, Dan Hua, Yiping Hong, Xi Cheng, Fangsong Guo, Kok Bing Tan, Ziqi Zhong, Guowu Zhan. (2023) Design of hybrid g-C3N4/GO/MCE photocatalytic membranes with enhanced separation performance under visible-light irradiation. CHEMICAL ENGINEERING JOURNAL, 466 (143164). [PMID:] [10.1016/j.cej.2023.143164] |
9. Xiu-Yan Li, Yu-Ting Luo, Yan-Hong Wang, Zhi-Xin Yang, Yu-Zhou Shang, Qing-Xia Guan. (2023) Anti-inflammatory effect and antihepatoma mechanism of carrimycin. WORLD JOURNAL OF GASTROENTEROLOGY, 29 (14): ( 2134–2152). [PMID:37122599] [10.3748/wjg.v29.i14.2134] |
10. Dan Liu, Jiahui Ji, Xinran Guo, Sanhu Gou, Xinyue Chen. (2023) Syringe Paper-Based Analytical Device for Thiamazole Detection by Hedysarum Polysaccharides-Mediated Silver Nanoparticles. Micromachines, 14 (2): (350). [PMID:36838050] [10.3390/mi14020350] |
11. Yu Wang, Yunxiang He, Qin Wang, Xiaoling Wang, Blaise L. Tardy, Joseph J. Richardson, Orlando J. Rojas, Junling Guo. (2023) Microporous membranes for ultrafast and energy-efficient removal of antibiotics through polyphenol-mediated nanointerfaces. Matter, 6 (260-273). [PMID:] [10.1016/j.matt.2022.09.021] |
12. Zheng Jiahong, Yang Yamei, Cheng Kangkang, Ma Junyu, Yu Pengfei. (2022) Mesoporous silica nanoparticles encapsulated carbon quantum dots for detection of tetracycline. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS, 33 (21): (17036-17047). [PMID:] [10.1007/s10854-022-08581-3] |
13. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] [10.1016/j.mcpro.2022.100248] |
14. Chengan Guo, Zhaoyin Diao, Jianli Liu, Baokun Yang, Jian Zhang. (2022) Quantification and evaluation of ion transmission efficiency in two-stage vacuum chamber miniature mass spectrometer. JOURNAL OF MASS SPECTROMETRY, 57 (3): (e4816). [PMID:35229406] [10.1002/jms.4816] |
15. Ou Panpan, Wu Jiawen, Lin Yu, Tan Xuecai, Wu Yeyu, Chen Zhifan, Wei Fucun, Huang Kejing. (2022) Flexible photoelectrochemical sensor for highly sensitive chloramphenicol detection based on M-TiO2-CdTe QDs/CdS QDs composite. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (6): (2065-2078). [PMID:34984509] [10.1007/s00216-021-03840-4] |
16. Peng Zhang, Guanghua Lu, Yu Sun, Zhenhua Yan, Tianjian Dang, Jianchao Liu. (2022) Metagenomic analysis explores the interaction of aged microplastics and roxithromycin on gut microbiota and antibiotic resistance genes of Carassius auratus. JOURNAL OF HAZARDOUS MATERIALS, 425 (127773). [PMID:34802820] [10.1016/j.jhazmat.2021.127773] |
17. Yu Wang, Jin-Yi Yang, Ying He, Lu Li, Jian-Xin Huang, Yuan-Xin Tian, Hong Wang, Zhen-Lin Xu, Yu-Dong Shen. (2021) Development of Time-Resolved Fluorescence Immunochromatographic Assays for Simultaneously Detecting Tylosin and Tilmicosin in Milk in Group-Screening Manner. Foods, 10 (8): (1838). [PMID:34441616] [10.3390/foods10081838] |
18. Huiling Zhang, Xiansheng Zhang, Lei Liu, Xiaoyu Pang, Langfei Yang, Bingjie Xu, Jindan Wu, Dongming Qi. (2021) Synergistic bactericidal nanofibers with photothermal controlled release of antibiotics triggered by near infrared. MATERIALS LETTERS, 302 (130423). [PMID:] [10.1016/j.matlet.2021.130423] |
19. Zhou Chen, Yanzeng Li, Yanyan Peng, Chengsong Ye, Shenghua Zhang. (2021) Effects of antibiotics on hydrolase activity and structure of microbial community during aerobic co-composting of food waste with sewage sludge. BIORESOURCE TECHNOLOGY, 321 (124506). [PMID:33310386] [10.1016/j.biortech.2020.124506] |
20. Ziming Zhao, Yanzhu Guo, Tao Zhang, Jiliang Ma, Haiming Li, Jinghui Zhou, Zhiwei Wang, Runcang Sun. (2020) Preparation of carbon dots from waste cellulose diacetate as a sensor for tetracycline detection and fluorescence ink. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 164 (4289). [PMID:32891644] [10.1016/j.ijbiomac.2020.08.243] |
21. Yunlei Zhou, Yue Wang, Shurong Li, Xi Fang, Huanshun Yin, Po Wang, Shiyun Ai. (2020) A novel photoelectrochemical immunosensor for N1-methyladenine detection based on BiVO4/g-C3N4 heterojunction with signal amplification of TiO2@NH2-MIL-125(Ti). SENSORS AND ACTUATORS B-CHEMICAL, 318 (128310). [PMID:] [10.1016/j.snb.2020.128310] |
22. Nana Xue, Liyi Wang, Wenfeng Li, Shanshan Wang, Xiangliang Pan, Daoyong Zhang. (2020) Increased inheritance of structure and function of bacterial communities and pathogen propagation in plastisphere along a river with increasing antibiotics pollution gradient. ENVIRONMENTAL POLLUTION, 265 (114641). [PMID:32505934] [10.1016/j.envpol.2020.114641] |
23. Yueran Zhu, Yunguang Lu, Longyan Shi, Yaling Yang. (2020) β-Cyclodextrin functionalized N,Zn codoped carbon dots for specific fluorescence detection of fluoroquinolones in milk samples. MICROCHEMICAL JOURNAL, 153 (104517). [PMID:] [10.1016/j.microc.2019.104517] |
24. Guo Feng, Zhu Zihan, Zheng Zhangqin, Jin Ying, Di Xiaoxuan, Xu Zhonghao, Guan Hongwei. (2020) Facile synthesis of highly efficient fluorescent carbon dots for tetracycline detection. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 27 (4): (4520-4527). [PMID:31768961] [10.1007/s11356-019-06779-3] |
25. Baoyi Cai, Tian Zhong, Peizhou Chen, Jia Fu, Yuanbao Jin, Yinglei Liu, Ran Huang, Lianjiang Tan. (2018) Preparation, characterization and in vitro release study of drug-loaded sodium carboxy-methylcellulose/chitosan composite sponge. PLoS One, 13 (10): (e0206275). [PMID:30346976] [10.1371/journal.pone.0206275] |
26. Chan-Yuan YAO, Jin-Yi YANG, Zhen-Lin XU, Hong WANG, Hong-Tao LEI, Yuan-Ming SUN, Yuan-Xin TIAN, Yu-Dong SHEN. (2018) Indirect Competitive Enzyme-Linked Immunosorbent Assay for Detection of Tylosin in Milk and Water Samples. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 46 (1275). [PMID:] [10.1016/S1872-2040(18)61106-5] |
27. Li'na Qiao, Sihua Qian, Yuhui Wang, Shifeng Yan, Hengwei Lin. (2018) Carbon-Dots-Based Lab-On-a-Nanoparticle Approach for the Detection and Differentiation of Antibiotics. CHEMISTRY-A EUROPEAN JOURNAL, 24 (18): (4703-4709). [PMID:29369443] [10.1002/chem.201706056] |
1. Chantot JF, Bryskier A, Gasc JC. (1986) Antibacterial activity of roxithromycin: a laboratory evaluation.. J Antibiot (Tokyo), 39 (5): (660-8). [PMID:3733515] [10.1021/op500134e] |
2. Jun Yao. (2024) A multiple signal amplification photoelectrochemical biosensor based on biotin-avidin system for kanamycin sensing in fish and milk via synergism of g-C3N4 and Ru@SiO2. ANALYTICA CHIMICA ACTA, 1288 (342141). [PMID:38220276] [10.1016/j.aca.2023.342141] |
3. Xiaoyu Zhang, Peiran Meng, Wei Wang, Xiwen Li, Zuan Yang, Shaokai Du, Yue Sun. (2023) Simultaneous Electrochemical Determination of Erythromycin and Hemoglobin by Flexible Carbon Cloth Modified with ZnO Nanorod Arrays and Au Nanoparticles by Differential Pulse Voltammetry (DPV). ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2023.2292664] |
4. Qing Fang, Qin Liu, Zongli Xie, Matthew R. Hill, Kaisong Zhang. (2024) Ultra-thin PTMSP nanocomposite membranes incorporated with functionalized MoS2 nanosheets for pharmaceutical concentration and solvent recovery. SEPARATION AND PURIFICATION TECHNOLOGY, 330 (125296). [PMID:16479015] [10.1016/j.seppur.2023.125296] |
5. Jutao Hu, Xiaoyu Su, Lei Yuan, Kaiyi Zheng, Xiaobo Zou, Zongbao Sun, Xuechao Xu, Wen Zhang. (2023) Competitive immunoassay using enzyme-regulated Fe3O4@COF/Fe3+ fluorescence probe for natural chloramphenicol detection. ANALYTICA CHIMICA ACTA, 1277 (341680). [PMID:37604605] [10.1016/j.aca.2023.341680] |
6. Zhiwen Li, Zhilin Zhou, Jianghua Wang, Tingxian Tao, Yingqiang Fu. (2023) Aggregation-induced emission enhancement N, S-CQDs for selective detection of CIP in the environment. NANOTECHNOLOGY, 34 (39): (395503). [PMID:37343538] [10.1088/1361-6528/ace05a] |
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