Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab170571-100μg | 100μg | In stock | $79.90 | |
| Ab170571-1mg | 1mg | In stock | $357.90 | |
| Ab170571-5mg | 5mg | In stock | $717.90 | |
| Ab170571-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,167.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Rozanolixizumab (anti-FCGRT) - Primary antibody, for ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt various applications, specific to FCGRT, >95%, high purity |
|---|---|
| Synonyms | UCB7665; Anti-FcRn (FCGRT & B2M) Reference Antibody (rozanolixizumab) ; Alpha chain antibody; Fc fragment of IgG, receptor transporter, alpha antibody; FCGRN_HUMAN antibody; FCGRT antibody; FcRn alpha chain antibody; FcRn antibody; FCRN, alpha chain antib |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Specificity | FCGRT |
| Application | ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | Antibody of Fc fragment of IgG receptor and transporter |
| Product Description | Rozanolixizumab (anti-FCGRT) , a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), is used to the research of reducing pathogenic IgG in autoimmune and alloimmune diseases. Purity： >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg |
| Antibody Type | Primary antibody |
|---|---|
| Clonality | Recombinant |
| Isotype | Human IgG4SP |
| Light Chain Type | kappa |
| SDS-PAGE | 26.8 kDa (Light Chain) & 51.8 kDa (Heavy Chain), under reducing conditions; 174.5 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Source | CHO supernatant |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 1584645-37-3 |
Rozanolixizumab (anti-FCGRT) (Ab170571) - ELISA
Immobilized Rozanolixizumab (anti-FCGRT) (Ab170571) at 2 μg/mL can bind FcRn(FCGRT)-chis+FcRn(B2M)-Strep II with the EC₅₀ of 10.29 ng/mL.
Rozanolixizumab (anti-FCGRT) (Ab170571) - SEC
The purity of Rozanolixizumab (anti-FCGRT) (Ab170571) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0303690 | Certificate of Analysis | Mar 25, 2024 | Ab170571 |
| ZJ24F0303689 | Certificate of Analysis | Mar 25, 2024 | Ab170571 |
| ZJ24F0303688 | Certificate of Analysis | Mar 25, 2024 | Ab170571 |
| 1. Kiessling P, Lledo-Garcia R, Watanabe S, Langdon G, Tran D, Bari M, Christodoulou L, Jones E, Price G, Smith B et al.. (2017) The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: A randomized phase 1 study.. Sci Transl Med, 9 (414): (589-97). [PMID:29093180] |
| 2. Nixon AE, Chen J, Sexton DJ, Muruganandam A, Bitonti AJ, Dumont J, Viswanathan M, Martik D, Wassaf D, Mezo A et al.. (2015) Fully human monoclonal antibody inhibitors of the neonatal fc receptor reduce circulating IgG in non-human primates.. Front Immunol, 6 (3): (176). [PMID:25954273] |
| 3. McDonnell KA, Low SC, Hoehn T, Donnelly R, Palmieri H, Fraley C, Sakorafas P, Mezo AR.. (2010) Synthesis and structure-activity relationships of dimeric peptide antagonists of the human immunoglobulin G-human neonatal Fc receptor (IgG-FcRn) interaction.. J Med Chem, 53 (4): (1587-1596). [PMID:20092334] |
| 4. Story, C M CM, Mikulska, J E JE and Simister, N E NE.. (1994) A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus.. The Journal of experimental medicine, (1): [PMID:7964511] |
| 5. West, A P AP and Bjorkman, P J PJ.. (2000) Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,).. Biochemistry, (15): [PMID:10933786] |
| 6. Mikulska, J E JE, Pablo, L L, Canel, J J and Simister, N E NE.. (2000) Cloning and analysis of the gene encoding the human neonatal Fc receptor.. European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics, [PMID:10998088] |
| 7. Oganesyan, Vaheh V and 6 more authors.. (2014) Structural insights into neonatal Fc receptor-based recycling mechanisms.. The Journal of biological chemistry, (14): [PMID:24469444] |
| 8. Morosky, Stefanie S and 6 more authors.. (2019) The neonatal Fc receptor is a pan-echovirus receptor.. Proceedings of the National Academy of Sciences of the United States of America, (26): [PMID:30808762] |
| 9. Zhao, Xin X and 27 more authors.. (2019) Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.. Cell, (30): [PMID:31104841] |
