IL-10, CAS No.rp174275, Agonist of Interleukin-10 receptor;Agonist of Interleukin 10 receptor; α subunit

Features and benefits
    Item Number
    rp174275
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp174275-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp174275-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90

    Basic Description

    Product NameIL-10, CAS No.rp174275
    Synonymsinterleukin-10
    GradeMoligand™
    Specifications & PurityMoligand™
    Action TypeAGONIST
    Mechanism of actionAgonist of Interleukin-10 receptor;Agonist of Interleukin 10 receptor; α subunit

    Associated Targets(Human)

    IL10RA Tbio Interleukin-10 receptor subunit alpha (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    IL10RB Tbio Interleukin-10 receptor subunit beta (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    CASrp174275

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Alternate Namesinterleukin-10
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. O'Garra A, Vieira P.  (2007)  T(H)1 cells control themselves by producing interleukin-10..  Nat Rev Immunol,  (6): (425-8).  [PMID:17525751] [10.1021/op500134e]
    2. Schwager K, Kaspar M, Bootz F, Marcolongo R, Paresce E, Neri D, Trachsel E.  (2009)  Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis..  Arthritis Res Ther,  11  (5): (R142).  [PMID:19781067] [10.1021/op500134e]
    3. Ryan JJ, Kashyap M, Bailey D, Kennedy S, Speiran K, Brenzovich J, Barnstein B, Oskeritzian C, Gomez G.  (2007)  Mast cell homeostasis: a fundamental aspect of allergic disease..  Crit Rev Immunol,  27  (1): (15-32).  [PMID:17430094] [10.1021/op500134e]
    4. Fillatreau S, Gray D, Anderton SM.  (2008)  Not always the bad guys: B cells as regulators of autoimmune pathology..  Nat Rev Immunol,  (5): (391-7).  [PMID:18437156] [10.1021/op500134e]
    5. Naing A, Papadopoulos KP, Autio KA, Ott PA, Patel MR, Wong DJ, Falchook GS, Pant S, Whiteside M, Rasco DR et al..  (2016)  Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors..  J Clin Oncol,  34  (29): (3562-3569).  [PMID:27528724] [10.1021/op500134e]
    6. Naing A, Infante JR, Papadopoulos KP, Chan IH, Shen C, Ratti NP, Rojo B, Autio KA, Wong DJ, Patel MR et al..  (2018)  PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients..  Cancer Cell,  34  (5): (775-791.e3).  [PMID:30423297] [10.1021/op500134e]

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