Skip to the beginning of the images gallery

RS 102895 - 98%, high purity , CAS No.300815-41-2, Antagonist of CCR2

Moligand™
≥98%

CAS#: 300815-41-2
Formula: C₂₁H₂₁F₃N₂O₂
Molecular Weight: 390.40
PubChem CID: 16759153

Item Number

R335959

Grouped product items
SKU	Size	Availability	Price
R335959-1mg	1mg	In stock	$20.90
R335959-5mg	5mg	In stock	$77.90
R335959-10mg	10mg	In stock	$118.90
R335959-25mg	25mg	In stock	$267.90
R335959-50mg	50mg	In stock	$470.90
R335959-100mg	100mg	In stock	$846.90

a CCR2-selective chemokine receptor antagonist

View related series

CCR2 Antagonist

Basic Description

Synonyms	RS 102895 hydrochloride\|1173022-16-6\|300815-41-2\|RS-102895 Hydrochloride\|RS102895 hydrochloride\|RS102895 (hydrochloride)\|MFCD08703093\|1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one;hydrochloride\|Spiro[4H-3,1-benzoxa
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CCR2
Product Description	RS 102895 Hydrochloride is a CKR-2B (CCR2)-selective chemokine receptor antagonist (IC\|50\|values are 0.36 and 17.8 μM for inhibition of human recombinant CKR-2B and CKR-1 (CCR2b and CCR1 receptors) respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC\|50\|values of 32 nM and 1.7 μM respectively. Inhibits α\|1A\|-AR, α\|1D\|-AR and SR-1A (α1A, α1D and 5-HT\|1A\|receptors).

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CCR2 Tchem C-C chemokine receptor type 2 1 Activities

Discover Target: CCR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FTL Tbio Ferritin light chain 0 Activities

Discover Target: FTL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMN1 Tchem Survival motor neuron protein 0 Activities

Discover Target: SMN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TSHR Tclin Thyrotropin receptor 0 Activities

Discover Target: TSHR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX15B Tchem Arachidonate 15-lipoxygenase B 0 Activities

Discover Target: ALOX15B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Discover Target: ALOX15

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Discover Target: APEX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau 0 Activities

Discover Target: MAPT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TP53 Tchem Cellular tumor antigen p53 0 Activities

Discover Target: TP53

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one;hydrochloride
INCHI	InChI=1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H
InChi Key	KRRISOFSWVKYBF-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F.Cl
Isomeric SMILES	C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F.Cl
WGK Germany	3
PubChem CID	16759153
Molecular Weight	390.40

PubChem CID

CAS Registry No.

ChEMBL Ligand

RCSB PDB Ligand

GPCRdb Ligand

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

12 results found

Lot Number	Certificate Type	Date	Item
F2309922	Certificate of Analysis	May 10, 2023	R335959
F2310469	Certificate of Analysis	May 10, 2023	R335959
F2310473	Certificate of Analysis	May 10, 2023	R335959
F2310475	Certificate of Analysis	May 10, 2023	R335959
F2310477	Certificate of Analysis	May 10, 2023	R335959
F2310479	Certificate of Analysis	May 10, 2023	R335959
F2310481	Certificate of Analysis	May 10, 2023	R335959
F2310485	Certificate of Analysis	May 10, 2023	R335959
F2310486	Certificate of Analysis	May 10, 2023	R335959
F2310488	Certificate of Analysis	May 10, 2023	R335959
F2310493	Certificate of Analysis	May 10, 2023	R335959
F2310495	Certificate of Analysis	May 10, 2023	R335959

Solubility

Soluble in DMSO (75 mM).

Sensitivity

Moisture sensitive

Refractive Index

n20D~1.59 (Predicted)

References

1. Mirzadegan T, Diehl F, Ebi B, Bhakta S, Polsky I, McCarley D, Mulkins M, Weatherhead GS, Lapierre JM, Dankwardt J et al.. (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle.. J Biol Chem, 275 (33): (25562-71). [PMID:10770925]
2. Clark RD, Caroon JM, Kluge AF, Repke DB, Roszkowski AP, Strosberg AM, Baker S, Bitter SM, Okada MD. (1983) Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones.. J Med Chem, 26 (5): (657-61). [PMID:6842505]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.