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(RS)-3,5-DHPG - ≥99%(HPLC), high purity , CAS No.146255-66-5, Agonist of mGlu 1 receptor;Agonist of mGlu 5 receptor

  • Moligand™
  • ≥99%(HPLC)
Item Number
R287455
Grouped product items
SKUSizeAvailabilityPrice Qty
R287455-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$12.90
R287455-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$199.90

Selective group I mGlu agonist

Basic Description

Synonyms3,5-Dihydroxyphenylglycine|(RS)-3,5-DHPG|146255-66-5|2-amino-2-(3,5-dihydroxyphenyl)acetic acid|3,5-Dhpg|(RS)-3,5-Dihydroxyphenylglycine|DL-3,5-dihydroxyphenylglycine|5YR2N37E6D|(+/-)-3,5-DHPG HCl|alpha-Amino-3,5-dihydroxybenzeneacetic acid|UNII-5YR2N37E6
Specifications & PurityMoligand™, ≥99%(HPLC)
Biochemical and Physiological MechanismsSelective group I metabotropic glutamate receptor agonist which activates both mGlu1and mGlu5. Also reported to be an antagonist at metabotropic glutamate receptors linked to phospholipase D.S-enantiomeralso available.
Storage TempStore at -20°C,Argon charged,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of mGlu 1 receptor;Agonist of mGlu 5 receptor
Product Description

Product Describtion:

DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs[1]. DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluRs linked to phospholipase D.

Associated Targets

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RECQL Tbio ATP-dependent DNA helicase Q1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC1A5 Tchem Neutral amino acid transporter B(0) 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM1 Tchem Metabotropic glutamate receptor 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM5 Tchem Metabotropic glutamate receptor 5 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

IMPA1 Tclin Inositol monophosphatase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-amino-2-(3,5-dihydroxyphenyl)acetic acid
INCHI InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)
InChi Key HOOWCUZPEFNHDT-UHFFFAOYSA-N
Canonical SMILES C1=C(C=C(C=C1O)O)C(C(=O)O)N
Isomeric SMILES C1=C(C=C(C=C1O)O)C(C(=O)O)N
PubChem CID 108001
Molecular Weight 183.16

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySolvent:water, Max Conc. mg/mL: 1.83, Max Conc. mM: 10

Related Documents

Solution Calculators