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(RS)-3,5-DHPG - ≥99%(HPLC), high purity , CAS No.146255-66-5, Agonist of mGlu 1 receptor;Agonist of mGlu 5 receptor

Item Number
R287455
Grouped product items
SKUSizeAvailabilityPrice Qty
R287455-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$12.90
R287455-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$199.90

Selective group I mGlu agonist

Basic Description

SynonymsSR-01000597610 | (+/-)-3,5-DHPG HCl | SCHEMBL1512962 | DL-2-(3,5-DIHYDROXYPHENYL)GLYCINE | HB0026 | BRD-A20589515-001-01-1 | 2-amino-2-(3,5-dihydroxyphenyl)acetic acid | 2-amino-2-(3,5-dihydroxyphenyl)-acetic acid | DTXSID901311536 | J-012694 | CS-0020572
Specifications & PurityMoligand™, ≥99%(HPLC)
Biochemical and Physiological MechanismsSelective group I metabotropic glutamate receptor agonist which activates both mGlu1and mGlu5. Also reported to be an antagonist at metabotropic glutamate receptors linked to phospholipase D.S-enantiomeralso available.
Storage TempStore at -20°C,Argon charged,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of mGlu 1 receptor;Agonist of mGlu 5 receptor
Product Description

Product Describtion:

DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs[1]. DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluRs linked to phospholipase D.

Associated Targets(Human)

GRM1 Tchem Metabotropic glutamate receptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRM5 Tchem Metabotropic glutamate receptor 5 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
DNA-(apurinic or apyrimidinic site) lyase inhibitorINHIBITORALA5619DNA-(apurinic or apyrimidinic site) lyaseSINGLE PROTEINHomo sapiens

Other: [1]


Names and Identifiers

IUPAC Name 2-amino-2-(3,5-dihydroxyphenyl)acetic acid
INCHI InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)
InChi Key HOOWCUZPEFNHDT-UHFFFAOYSA-N
Canonical SMILES C1=C(C=C(C=C1O)O)C(C(=O)O)N
Isomeric SMILES C1=C(C=C(C=C1O)O)C(C(=O)O)N
PubChem CID 108001
Molecular Weight 183.16

Certificates

C of A & Other Certificates

Chemical and Physical Properties

SolubilitySolvent:water, Max Conc. mg/mL: 1.83, Max Conc. mM: 10

Related Documents

Solution Calculators