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(RS)-4-Bromo-homo-ibotenic acid , CAS No.71366-32-0
a potent AMPA receptor agonist
Basic Description
| Synonyms | 2-Amino-3-(4-bromo-3-hydroxy-isoxazol-5-yl)-propionic acid | BR-HIBO | 3-(4-bromo-3-hydroxyisoxazol-5-yl)alanine | 3-(4-Bromo-3-hydroxy-1,2-oxazol-5-yl)alanine | AB44069 | (RS)-4-Bromo-homo-ibotenic acid | (+/-)-4-Bromohomoibotenic acid, solid | SCHEMBL52 |
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| Storage Temp | Store at 2-8°C |
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| Shipped In | Wet ice |
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| Product Description | (RS)-4-Bromo-homo-ibotenic acid is a potent GluR (AMPA receptor) agonist. Selective but relatively non-potent group I mGluR agonist. |
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Product Properties
| pKa | pKₐ: 1.88 (Predicted), pKₐ: 8 (Predicted) |
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| Ki Data | GluR-1: Ki= 170 nM (human); GluR-2: Ki= 250 nM (human); GluR-4: Ki= 11.7 μM (human); GluR-3: Ki= 12 μM (human); NMDA epsilon 3: Ki= 34 μM (rat) |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 2-amino-3-(4-bromo-3-oxo-1,2-oxazol-5-yl)propanoic acid |
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| INCHI | InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12) |
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| InChi Key | JRTOQOAGTSUNHA-UHFFFAOYSA-N |
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| Canonical SMILES | C(C1=C(C(=O)NO1)Br)C(C(=O)O)N |
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| Isomeric SMILES | C(C1=C(C(=O)NO1)Br)C(C(=O)O)N |
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| WGK Germany | 3 |
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| PubChem CID | 2733518 |
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| Molecular Weight | 251 |
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Chemical and Physical Properties
| Solubility | Soluble in water (moderately), dilute aqueous base, and 1 eq. NaOH (10 mM). |
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| Refractive Index | n20D1.62 (Predicted) |
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| Boil Point(°C) | 443.3° C at 760 mmHg (Predicted) |
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| Melt Point(°C) | 301.65° C (Predicted) |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS06 |
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| Signal | Danger |
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| Hazard Statements | H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled |
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| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately. |
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| WGK Germany | 3 |
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