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RSL3 - 98%, high purity , CAS No.1219810-16-8

  • ≥98%
Item Number
R302648
Grouped product items
SKUSizeAvailabilityPrice Qty
R302648-1mg
1mg
In stock
$9.90
R302648-5mg
5mg
In stock
$29.90
R302648-10mg
10mg
In stock
$39.90
R302648-25mg
25mg
In stock
$79.90
R302648-50mg
50mg
In stock
$119.90
R302648-100mg
100mg
In stock
$189.90
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Induces ferroptosis; inhibits glutathione peroxidase 4 (GPX4)

View related series
Apoptosis Autophagy Metabolic Enzyme/Protease

Basic Description

Synonyms(1S,3R)-RSL3
Specifications & Purity98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells

Associated Targets

GPX4 Tchem Phospholipid hydroperoxide glutathione peroxidase 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate
INCHI InChI=1S/C23H21ClN2O5/c1-30-22(28)14-9-7-13(8-10-14)21-20-16(15-5-3-4-6-17(15)25-20)11-18(23(29)31-2)26(21)19(27)12-24/h3-10,18,21,25H,11-12H2,1-2H3/t18-,21+/m1/s1
InChi Key TXJZRSRTYPUYRW-NQIIRXRSSA-N
Canonical SMILES COC(=O)C1CC2=C(C(N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24
Isomeric SMILES COC(=O)[C@H]1CC2=C([C@@H](N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24
PubChem CID 1750826
Molecular Weight 440.88

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45 results found

Lot NumberCertificate TypeDateItem
F2403197Certificate of AnalysisMay 08, 2024 R302648
F2403196Certificate of AnalysisMay 08, 2024 R302648
F2403195Certificate of AnalysisMay 08, 2024 R302648
F2403194Certificate of AnalysisMay 08, 2024 R302648
F2403193Certificate of AnalysisMay 08, 2024 R302648
K2307248Certificate of AnalysisOct 30, 2023 R302648
K2307204Certificate of AnalysisOct 30, 2023 R302648
K2307205Certificate of AnalysisOct 30, 2023 R302648
K2307206Certificate of AnalysisOct 30, 2023 R302648
K2307208Certificate of AnalysisOct 30, 2023 R302648
K2307209Certificate of AnalysisOct 30, 2023 R302648
K2307210Certificate of AnalysisOct 30, 2023 R302648
K2307211Certificate of AnalysisOct 30, 2023 R302648
K2307215Certificate of AnalysisOct 30, 2023 R302648
K2307217Certificate of AnalysisOct 30, 2023 R302648
K2307218Certificate of AnalysisOct 30, 2023 R302648
K2307228Certificate of AnalysisOct 30, 2023 R302648
H2323538Certificate of AnalysisAug 02, 2023 R302648
H2323568Certificate of AnalysisAug 02, 2023 R302648
H2323567Certificate of AnalysisAug 02, 2023 R302648
H2323566Certificate of AnalysisAug 02, 2023 R302648
H2323551Certificate of AnalysisAug 02, 2023 R302648
H2323512Certificate of AnalysisAug 02, 2023 R302648
C23161107Certificate of AnalysisMar 09, 2023 R302648
C2317023Certificate of AnalysisMar 09, 2023 R302648
C2317088Certificate of AnalysisMar 09, 2023 R302648
C2317090Certificate of AnalysisMar 09, 2023 R302648
B2320614Certificate of AnalysisDec 30, 2022 R302648
B2320518Certificate of AnalysisDec 30, 2022 R302648
B2320618Certificate of AnalysisDec 30, 2022 R302648
B2320619Certificate of AnalysisDec 30, 2022 R302648
B2320620Certificate of AnalysisDec 30, 2022 R302648
B2320621Certificate of AnalysisDec 30, 2022 R302648
K2212620Certificate of AnalysisSep 02, 2022 R302648
K2212619Certificate of AnalysisSep 02, 2022 R302648
K2212608Certificate of AnalysisSep 02, 2022 R302648
K2212592Certificate of AnalysisSep 02, 2022 R302648
K2212562Certificate of AnalysisSep 02, 2022 R302648
K2212561Certificate of AnalysisSep 02, 2022 R302648
G2220794Certificate of AnalysisJun 17, 2022 R302648
G2220793Certificate of AnalysisJun 17, 2022 R302648
G2220792Certificate of AnalysisJun 17, 2022 R302648
G2220795Certificate of AnalysisJun 17, 2022 R302648
G2220796Certificate of AnalysisJun 17, 2022 R302648
G2220797Certificate of AnalysisJun 17, 2022 R302648

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 44.09, Max Conc. mM: 100
SensitivityMoisture sensitive

Safety and Hazards(GHS)

RIDADR NONHforallmodesoftransport

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. RSL3 - 10mM in DMSO, used for , CAS No. 1219810-16-8(DMSO), by Aladdin Scientific
    RSL3

    Starting at $159.90

References

1. 孙世博.  (2024)  Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif.  Redox biology,  70  (70): (103050).  [PMID:]
2. Xiaosi Lin , Le Dong, Qing Miao, Zhaobin Huang, Fang Wang.  (2024)  Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745T induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in non-small cell lung cancer cell lines.  European Journal of Pharmacology,  无  (974): (176608).  [PMID:38663542]

Solution Calculators

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