RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells
1.Haoze Song, Jing Liang, Yuanyuan Guo, Yang Liu, Kuiru Sa, Guohong Yan, Wen Xu, Wei Xu, Lixia Chen, Hua Li. (2024) A potent GPX4 degrader to induce ferroptosis in HT1080 cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 265 (116110). [PMID:38194774]
2.Weili Wu, Yingying Zhao, Baifu Qin, Xin Jiang, Chuyue Wang, Rong Hu, Rui Ma, Mong-Hong Lee, Huanliang Liu, Kai Li, Ping Yuan. (2023) Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer. EBioMedicine, 93 [PMID:37343364]
3.Zhao Hongting, Zhang Meng, Zhang Jinghua, Sun Zichen, Zhang Wenxin, Dong Weichen, Cheng Chen, Yao Yongzhong, Li Kuanyu. (2023) Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth. Cell and Bioscience, 13 (1):(1-15). [PMID:37179385]
4.Yu-Chen Chen, Qiong Zheng, Hui Lu, Yi-Xin Zhuang, Ting-Ting Gong, Lie-Feng Ma, Zha-Jun Zhan. (2023) Neuroprotective flavonoids from Epimedium brevicornu by inhibition of ferroptosis. Phytochemistry Letters, 55 (80). [PMID:]
5.Fan Zhang, Hualong Zhen, Hengshun Cheng, Fengying Hu, Yunfei Jia, Binbin Huang, Minmin Jiang. (2022) Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice. Frontiers in Cell and Developmental Biology, 10 (1014243). [PMID:36438553]
References
1.孙世博. (2024) Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif. Redox biology, 70 (70):(103050). [PMID:]
2.Xiaosi Lin , Le Dong, Qing Miao, Zhaobin Huang, Fang Wang. (2024) Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745T induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in non-small cell lung cancer cell lines. European Journal of Pharmacology, 无 (974):(176608). [PMID:38663542]
3.Haoze Song, Jing Liang, Yuanyuan Guo, Yang Liu, Kuiru Sa, Guohong Yan, Wen Xu, Wei Xu, Lixia Chen, Hua Li. (2024) A potent GPX4 degrader to induce ferroptosis in HT1080 cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 265 (116110). [PMID:38194774]
4.Weili Wu, Yingying Zhao, Baifu Qin, Xin Jiang, Chuyue Wang, Rong Hu, Rui Ma, Mong-Hong Lee, Huanliang Liu, Kai Li, Ping Yuan. (2023) Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer. EBioMedicine, 93 [PMID:37343364]
5.Zhao Hongting, Zhang Meng, Zhang Jinghua, Sun Zichen, Zhang Wenxin, Dong Weichen, Cheng Chen, Yao Yongzhong, Li Kuanyu. (2023) Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth. Cell and Bioscience, 13 (1):(1-15). [PMID:37179385]
6.Yu-Chen Chen, Qiong Zheng, Hui Lu, Yi-Xin Zhuang, Ting-Ting Gong, Lie-Feng Ma, Zha-Jun Zhan. (2023) Neuroprotective flavonoids from Epimedium brevicornu by inhibition of ferroptosis. Phytochemistry Letters, 55 (80). [PMID:]
7.Fan Zhang, Hualong Zhen, Hengshun Cheng, Fengying Hu, Yunfei Jia, Binbin Huang, Minmin Jiang. (2022) Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice. Frontiers in Cell and Developmental Biology, 10 (1014243). [PMID:36438553]
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