The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
runcaciguat , Soluble guanylate cyclase activator, CAS No.1402936-61-1, Soluble guanylate cyclase activator
Basic Description Synonyms Benzenepropanoic acid, 4-chloro-3-(((2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methyl-1-oxobutyl)amino)-beta-cyclopropyl-, (betaS)- | SCHEMBL20075857 | 1402936-61-1 | UNII-5EZ01YDT5S | AC-37098 | GTPL12359 | Runcaciguat [INN] | (3S)-3-(4-chloro-3-{[(2S, Specifications & Purity Moligand™ Grade Moligand™ Action Type ACTIVATOR Mechanism of action Soluble guanylate cyclase activator
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (3S)-3-[4-chloro-3-[[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino]phenyl]-3-cyclopropylpropanoic acid INCHI InChI=1S/C23H22Cl2F3NO3/c1-12(23(26,27)28)21(14-4-7-16(24)8-5-14)22(32)29-19-10-15(6-9-18(19)25)17(11-20(30)31)13-2-3-13/h4-10,12-13,17,21H,2-3,11H2,1H3,(H,29,32)(H,30,31)/t12-,17+,21+/m1/s1 InChi Key NCRMKIWHFXSBGZ-CNBXIYLPSA-N Canonical SMILES CC(C(C1=CC=C(C=C1)Cl)C(=O)NC2=C(C=CC(=C2)C(CC(=O)O)C3CC3)Cl)C(F)(F)F Isomeric SMILES C[C@H]([C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=C(C=CC(=C2)[C@@H](CC(=O)O)C3CC3)Cl)C(F)(F)F Alternate CAS 1402936-61-1 PubChem CID 134440946 MeSH Entry Terms BAY 1101042;runcaciguat Molecular Weight 488.3
References 1. Hahn MG, Lampe T, El Sheikh S, Griebenow N, Woltering E, Schlemmer KH, Dietz L, Gerisch M, Wunder F, Becker-Pelster EM et al. . (2021) Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042).. J Med Chem, 64 (9): (5323-5344). [PMID:33872507 ] [10.1021/op500134e ]
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
