Grouped product items

SKU

Size

Availability

Price

Qty

R288354-5mg

5mg

Available within 8-12 weeks(?)

$115.90

R288354-10mg

10mg

Available within 8-12 weeks(?)

$212.90

R288354-25mg

25mg

Available within 8-12 weeks(?)

$419.90

Basic Description

Synonyms	AG-7088 \| AG7088 \| Ethyl (E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[(5-methyl-1,2-oxazole-3-carbonyl)amino]-4-oxoheptanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Lupingquwei is a potent and selective irreversible human rhinovirus ( HRV ) 3C protease inhibitor ( EC50 = 5 nM ), which has also been found to inhibit enteroviruses and noroviruses. It has no obvious inhibitory effect on a variety of serine and cysteine
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Rupintrivir is an irreversible peptidomimetic inhibitor designed to target human rhinovirus (HRV). It was previously named as AG7088. It has been suggested that rupintrivir may be involved in vitro antiviral activity.

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRSS1 Tclin Trypsin I (2306 Activities)

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ELANE Tclin Leukocyte elastase (8173 Activities)

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CTSB Tchem Cathepsin B (3822 Activities)

Discover Target: CTSB

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Homo sapiens (32628 Activities)

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WI-38 (2654 Activities)

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HEK293 (82097 Activities)

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HeLa (62764 Activities)

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Associated Targets(non-human)

Alpha-chymotrypsin (819 Activities)

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CAPN1 Calpain 1 (219 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

protease Human rhinovirus A protease (1343 Activities)

Discover Target: protease

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Human rhinovirus sp. (1587 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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rhinovirus A39 (46 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Canis familiaris (36305 Activities)

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Mus musculus (284745 Activities)

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Echovirus E9 (43 Activities)

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Coxsackievirus B3 (1096 Activities)

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rhinovirus A1B (360 Activities)

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Enterovirus (1116 Activities)

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rhinovirus A2 (409 Activities)

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rhinovirus B14 (1052 Activities)

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rhinovirus A16 (69 Activities)

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Enterovirus A71 (1246 Activities)

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Vero (26788 Activities)

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Genome polyprotein (620 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Echovirus E6 (3 Activities)

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Plasma (328 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	ethyl (E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[(5-methyl-1,2-oxazole-3-carbonyl)amino]-4-oxoheptanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate
INCHI	InChI=1S/C31H39FN4O7/c1-5-42-27(38)11-10-24(16-21-12-13-33-29(21)39)34-30(40)22(15-20-6-8-23(32)9-7-20)17-26(37)28(18(2)3)35-31(41)25-14-19(4)43-36-25/h6-11,14,18,21-22,24,28H,5,12-13,15-17H2,1-4H3,(H,33,39)(H,34,40)(H,35,41)/b11-10+/t21-,22+,24+,28-/m0/s1
InChi Key	CAYJBRBGZBCZKO-BHGBQCOSSA-N
Canonical SMILES	CCOC(=O)C=CC(CC1CCNC1=O)NC(=O)C(CC2=CC=C(C=C2)F)CC(=O)C(C(C)C)NC(=O)C3=NOC(=C3)C
Isomeric SMILES	CCOC(=O)/C=C/[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](CC2=CC=C(C=C2)F)CC(=O)[C@H](C(C)C)NC(=O)C3=NOC(=C3)C
PubChem CID	6440352
Molecular Weight	598.66

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
C2412423	Certificate of Analysis	Jan 25, 2024	R288354
C2412429	Certificate of Analysis	Jan 25, 2024	R288354
C2412430	Certificate of Analysis	Jan 25, 2024	R288354
C2412431	Certificate of Analysis	Jan 25, 2024	R288354
C2412432	Certificate of Analysis	Jan 25, 2024	R288354
K2427334	Certificate of Analysis	Jan 25, 2024	R288354

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 59.87, Max Conc. mM: 100
Sensitivity	Light sensitive

Safety and Hazards(GHS)

RIDADR	NONHforallmodesoftransport

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Rupintrivir - ≥98%(HPLC), high purity , CAS No.223537-30-2

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
R288354-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$115.90
R288354-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$212.90
R288354-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$419.90