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Rutaecarpine - 98%, high purity , CAS No.84-26-4

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≥98%

CAS#: 84-26-4
Formula: C₁₈H₁₃N₃O
Molecular Weight: 287.32
MDL number: MFCD00210551
PubChem CID: 65752

Item Number

R107338

Grouped product items
SKU	Size	Availability	Price
R107338-50mg	50mg	In stock	$195.90
R107338-200mg	200mg	In stock	$705.90
R107338-250mg	250mg	In stock	$793.90
R107338-1g	1g	In stock	$2,857.90
R107338-5g	5g	In stock	$12,859.90

Indoloquinazoline alkaloid derived from Evodia rutaecarpa

View related series

azole Five-Membered Heterocyclic Compounds

Basic Description

Synonyms	C18H13N3O \| SMR001230721 \| RUTECARPINE [MI] \| Indolo[2',4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro- \| Rutaecarpine, >98% (HPLC) \| cid_65752 \| Rutacarpine \| Rutaecarpin \| UPCMLD-DP040 \| HMS3884P13 \| EN300-302963 \| Rutecarpine \| SW220226-1 \| HMS3656C
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Indoloquinazoline alkaloid derived from Evodia rutaecarpa . Various pharmacological actions in vitro and in vivo; anti-inflammatory, antinociceptive, vasorelaxant, antiplatelet aggregation. Pharmacologically active following oral administration.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (2 Activities)

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP1B1 Tchem Cytochrome P450 1B1 (2 Activities)

Discover Target: CYP1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (2 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP1A1 Tchem Cytochrome P450 1A1 (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE5A Tclin Phosphodiesterase 5A (5113 Activities)

Discover Target: PDE5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

Discover Target: HTR1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1B1 Tchem Cytochrome P450 1B1 (1148 Activities)

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POLB Tchem DNA polymerase beta (23632 Activities)

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TRPV1 Tclin Vanilloid receptor (8273 Activities)

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APP Tclin Amyloid-beta A4 protein (8510 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALB Tchem Serum albumin (2651 Activities)

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ARSA Tbio Cerebroside-sulfatase (655 Activities)

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CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)

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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

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NR1H2 Tchem LXR-beta (3841 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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Huh-7 (12904 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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RKO (1376 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SNB-19 (46794 Activities)

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SW480 (6023 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UO-31 (46270 Activities)

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Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cruzipain (33337 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Saccharomyces cerevisiae (19171 Activities)

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Plasmodium falciparum (966862 Activities)

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Rattus norvegicus (775804 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)

Discover Target: Trpa1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Danio rerio (3092 Activities)

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Aorta (2975 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PGAM 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (46 Activities)

Discover Target: PGAM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-1(21),2(10),4,6,8,15,17,19-octaen-14-one
INCHI	InChI=1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2
InChi Key	ACVGWSKVRYFWRP-UHFFFAOYSA-N
Canonical SMILES	C1CN2C(=NC3=CC=CC=C3C2=O)C4=C1C5=CC=CC=C5N4
Isomeric SMILES	C1CN2C(=NC3=CC=CC=C3C2=O)C4=C1C5=CC=CC=C5N4
WGK Germany	3
PubChem CID	65752
UN Number	2811
Molecular Weight	287.32

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
K2010333	Certificate of Analysis	Sep 14, 2024	R107338
I1523069	Certificate of Analysis	Jul 10, 2023	R107338
K2201673	Certificate of Analysis	Nov 17, 2022	R107338
K2201677	Certificate of Analysis	Nov 17, 2022	R107338
K2201691	Certificate of Analysis	Nov 17, 2022	R107338
K2201808	Certificate of Analysis	Nov 17, 2022	R107338
K2201809	Certificate of Analysis	Nov 17, 2022	R107338
A1902007	Certificate of Analysis	Oct 20, 2022	R107338

Chemical and Physical Properties

Solubility	Very slightly soluble in Ether,Chloroform,Benzene,Alcohol
Sensitivity	Heat Sensitive
Melt Point(°C)	262 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H300:Fatal if swallowed
Precautionary Statements	P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P264:Wash hands [and …] thoroughly after handling.
WGK Germany	3
Merck Index	8298

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yun Yang, Yuan Xiong, Guanghao Zhu, Mengru Sun, Kun Zou, Yitian Zhao, Yong Zhang, Zhijian Xu, Yiming Li, Weiliang Zhu, Qi Jia, Bo Li, Guangbo Ge. (2023) Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors. CHEMICO-BIOLOGICAL INTERACTIONS, 378 (110501). [PMID:37080375] [10.1016/j.cbi.2023.110501]
2. Xue-qi Liu, Juan Jin, Zeng Li, Ling Jiang, Yu-hang Dong, Yu-ting Cai, Ming-fei Wu, Jia-nan Wang, Tao-tao Ma, Jia-gen Wen, Ming-ming Liu, Jun Li, Yong-gui Wu, Xiao-ming Meng. (2020) Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy. BIOCHEMICAL PHARMACOLOGY, 180 (114132). [PMID:32622666] [10.1016/j.bcp.2020.114132]
3. Yao Sun, Pengfei Li, Ting Wang, Liting Qin, Gege Cheng, Liqun Shen, Xingdong Yao, Shaoping Wei, Jianxin Jiang, Fuhou Lei. (2019) Alkaloid purification using rosin-based polymer-bonded silica stationary phase in HPLC. JOURNAL OF SEPARATION SCIENCE, 42 (24): (3646-3652). [PMID:31613051] [10.1002/jssc.201900835]
4. Lushan Yu, Zhangting Wang, Minmin Huang, Yingying Li, Kui Zeng, Jinxiu Lei, Haihong Hu, Baian Chen, Jing Lu, Wen Xie, Su Zeng. (2016) Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1859 (1100). [PMID:26455953] [10.1016/j.bbagrm.2015.10.001]
5. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng. (2014) Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs. FOOD CHEMISTRY, 164 (74). [PMID:24996308] [10.1016/j.foodchem.2014.05.004]

References

1. Yun Yang, Yuan Xiong, Guanghao Zhu, Mengru Sun, Kun Zou, Yitian Zhao, Yong Zhang, Zhijian Xu, Yiming Li, Weiliang Zhu, Qi Jia, Bo Li, Guangbo Ge. (2023) Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors. CHEMICO-BIOLOGICAL INTERACTIONS, 378 (110501). [PMID:37080375] [10.1016/j.cbi.2023.110501]
2. Xue-qi Liu, Juan Jin, Zeng Li, Ling Jiang, Yu-hang Dong, Yu-ting Cai, Ming-fei Wu, Jia-nan Wang, Tao-tao Ma, Jia-gen Wen, Ming-ming Liu, Jun Li, Yong-gui Wu, Xiao-ming Meng. (2020) Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy. BIOCHEMICAL PHARMACOLOGY, 180 (114132). [PMID:32622666] [10.1016/j.bcp.2020.114132]
3. Yao Sun, Pengfei Li, Ting Wang, Liting Qin, Gege Cheng, Liqun Shen, Xingdong Yao, Shaoping Wei, Jianxin Jiang, Fuhou Lei. (2019) Alkaloid purification using rosin-based polymer-bonded silica stationary phase in HPLC. JOURNAL OF SEPARATION SCIENCE, 42 (24): (3646-3652). [PMID:31613051] [10.1002/jssc.201900835]
4. Lushan Yu, Zhangting Wang, Minmin Huang, Yingying Li, Kui Zeng, Jinxiu Lei, Haihong Hu, Baian Chen, Jing Lu, Wen Xie, Su Zeng. (2016) Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1859 (1100). [PMID:26455953] [10.1016/j.bbagrm.2015.10.001]
5. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng. (2014) Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs. FOOD CHEMISTRY, 164 (74). [PMID:24996308] [10.1016/j.foodchem.2014.05.004]

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Rutaecarpine - 98%, high purity , CAS No.84-26-4

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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