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Transmembrane Transporters
Voltage-gated ion channels
Potassium channels
RY796 , CAS No.R613349, Gating inhibitor of K v2.1;Gating inhibitor of K v2.2

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RY796 , CAS No.R613349, Gating inhibitor of K v2.1;Gating inhibitor of K v2.2

Moligand™

PubChem CID: 71719898

Item Number

R613349

Grouped product items
SKU	Size	Availability	Price	Qty
R613349-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
R613349-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

Kv2.1 Gating inhibitor Kv2.2 Gating inhibitor

Basic Description

Synonyms	RY 796;RY-796
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	GATING INHIBITOR
Mechanism of action	Gating inhibitor of K v2.1;Gating inhibitor of K v2.2

Associated Targets(Human)

KCNB1 Tclin Potassium voltage-gated channel subfamily B member 1 (1 Activities)

Discover Target: KCNB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNB2 Tclin Potassium voltage-gated channel subfamily B member 2 (2 Activities)

Discover Target: KCNB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-(dimethylamino)-5-(2-methylpropanoylamino)-N-[(1S)-1-phenylethyl]benzamide
INCHI	InChI=1S/C21H27N3O2/c1-14(2)20(25)23-17-11-12-19(24(4)5)18(13-17)21(26)22-15(3)16-9-7-6-8-10-16/h6-15H,1-5H3,(H,22,26)(H,23,25)/t15-/m0/s1
InChi Key	LDXZFQWWXMRMAS-HNNXBMFYSA-N
Canonical SMILES	O=C(C(C)C)Nc1ccc(c(c1)C(=O)N[C@H](c1ccccc1)C)N(C)C
Isomeric SMILES	C[C@@H](C1=CC=CC=C1)NC(=O)C2=C(C=CC(=C2)NC(=O)C(C)C)N(C)C
PubChem CID	71719898

Database links

PubChem CID	71719898
ChEMBL Ligand	CHEMBL2324356
BindingDB Ligand	50004798

Certificates

Certificate of Analysis(COA)

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References

1. Herrington J, Solly K, Ratliff KS, Li N, Zhou YP, Howard A, Kiss L, Garcia ML, McManus OB, Deng Q et al.. (2011) Identification of novel and selective Kv2 channel inhibitors.. Mol Pharmacol, 80 (6): (959-64). [PMID:21948463] [10.1021/op500134e]

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