Ryngo ® 1-23 - ≥97%, high purity , CAS No.171674-76-3

Item Number

R276450

Grouped product items
SKU	Size	Availability	Price
R276450-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$199.90
R276450-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$466.90
R276450-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$838.90
R276450-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,257.90
R276450-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,759.90

Dynamin activator. Endocytosis inhibitor.

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Basic Description

Synonyms	Bis-T-23 \| AG1717 \| (E)-2-cyano-N-[3-[[(E)-2-cyano-3-(3,4,5-trihydroxyphenyl)prop-2-enoyl]amino]propyl]-3-(3,4,5-trihydroxyphenyl)prop-2-enamide \| (2E,2'E)-N,N'-(propane-1,3-diyl)bis(2-cyano-3-(3,4,5-trihydroxyphenyl)acrylamide)
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	Dynamin activator; Stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity. Endocytosis inhibitor; Inhibits transferrin uptake by clathrin-mediated endocytosis in dendritic cells.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Note	Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD).

Names and Identifiers

IUPAC Name	(E)-2-cyano-N-[3-[[(E)-2-cyano-3-(3,4,5-trihydroxyphenyl)prop-2-enoyl]amino]propyl]-3-(3,4,5-trihydroxyphenyl)prop-2-enamide
INCHI	InChI=1S/C23H20N4O8/c24-10-14(4-12-6-16(28)20(32)17(29)7-12)22(34)26-2-1-3-27-23(35)15(11-25)5-13-8-18(30)21(33)19(31)9-13/h4-9,28-33H,1-3H2,(H,26,34)(H,27,35)/b14-4+,15-5+
InChi Key	AAPVOSBVTLGGOU-VHUAAIQRSA-N
Canonical SMILES	C1=C(C=C(C(=C1O)O)O)C=C(C#N)C(=O)NCCCNC(=O)C(=CC2=CC(=C(C(=C2)O)O)O)C#N
Isomeric SMILES	C1=C(C=C(C(=C1O)O)O)/C=C(/C(=O)NCCCNC(=O)/C(=C/C2=CC(=C(C(=C2)O)O)O)/C#N)\C#N
Molecular Weight	480.43

References

1. Lees JG et al.. (2015) Role of dynamin in elongated cell migration in a 3D matrix.. Biochim Biophys Acta, 1853 (3): (611-8). [PMID:25498249]
2. Jackson J et al.. (2015) Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release.. Mol Psychiatry, 20 (7): (810-9). [PMID:25939402]

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Basic Description