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Ryngo ® 1-23 - ≥97%, high purity , CAS No.171674-76-3

Item Number

R276450

Grouped product items
SKU	Size	Availability	Price	Qty
R276450-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$199.90

Dynamin activator. Endocytosis inhibitor.

Basic Description

Synonyms	(2E,2'E)-N,N'-1,3-Propanediylbis[2-cyano-3-(3,4,5-trihydroxyphenyl)-2-propenamide
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	Dynamin activator; Stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity. Endocytosis inhibitor; Inhibits transferrin uptake by clathrin-mediated endocytosis in dendritic cells.
Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Note	Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at -20°C. Store In the Dark. Store under desiccating conditions.

DNM1 Tbio Dynamin-1 (215 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IUPAC Name	(E)-2-cyano-N-[3-[[(E)-2-cyano-3-(3,4,5-trihydroxyphenyl)prop-2-enoyl]amino]propyl]-3-(3,4,5-trihydroxyphenyl)prop-2-enamide
INCHI	InChI=1S/C23H20N4O8/c24-10-14(4-12-6-16(28)20(32)17(29)7-12)22(34)26-2-1-3-27-23(35)15(11-25)5-13-8-18(30)21(33)19(31)9-13/h4-9,28-33H,1-3H2,(H,26,34)(H,27,35)/b14-4+,15-5+
InChi Key	AAPVOSBVTLGGOU-VHUAAIQRSA-N
Canonical SMILES	C1=C(C=C(C(=C1O)O)O)C=C(C#N)C(=O)NCCCNC(=O)C(=CC2=CC(=C(C(=C2)O)O)O)C#N
Isomeric SMILES	C1=C(C=C(C(=C1O)O)O)/C=C(/C(=O)NCCCNC(=O)/C(=C/C2=CC(=C(C(=C2)O)O)O)/C#N)\C#N
PubChem CID	5468833
Molecular Weight	480.4

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Solubility	Soluble in DMSO to 50 mM

1. Lees JG et al.. (2015) Role of dynamin in elongated cell migration in a 3D matrix.. Biochim Biophys Acta, 1853 (3): (611-8). [PMID:25498249]
2. Jackson J et al.. (2015) Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release.. Mol Psychiatry, 20 (7): (810-9). [PMID:25939402]

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