Nucleoside analog that competitively inhibits equilibrative nucleoside transporter 1 (ENT1) (IC 50 s = 4.6 and 3.6 nM for rat and human, respectively).
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
Product Description
S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR) is a small molecule inhibitor of equilibrative nucleoside transporter (ENT) proteins. These transport proteins are described in relation to their sensitivity to NBMPR, designated as either es (NBMPR-sensitive) or ei (NBMPR-insensitive). They provide good research tools anticancer, antiviral, cardioprotective, and neuroprotective agents. Inhibition of ENT1 by NBMPR blocks the uptake and transport of adenosine, which affects the regulation of extracellular adenosine levels and the cardiac system signaling associated with adenosine. An inhibitor of ENTs with potential anticancer, cardio-, and neuro- protective properties
1.Hongjun Chen, Chunhu Yu, Zeyang Xue, Pengxiang Wang, Zi Wang, Qianmin Cong, Lizhai Pei, Chuangang Fan. (2020) Synthesis of Li-doped bismuth oxide nanoplates, Co nanoparticles modification, and good photocatalytic activity toward organic pollutants. TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, [PMID:][10.1080/02772248.2020.1798448]
2.Yubin Xiang, Xue Lu, Jiangtao Yue, Yan Zhang, Xiaoyue Sun, Guilong Zhang, Dongqing Cai, Zhengyan Wu. (2020) Stimuli-responsive hydrogel as carrier for controlling the release and leaching behavior of hydrophilic pesticide. SCIENCE OF THE TOTAL ENVIRONMENT, 722 (137811). [PMID:32179301][10.1016/j.scitotenv.2020.137811]
References
1.Hongjun Chen, Chunhu Yu, Zeyang Xue, Pengxiang Wang, Zi Wang, Qianmin Cong, Lizhai Pei, Chuangang Fan. (2020) Synthesis of Li-doped bismuth oxide nanoplates, Co nanoparticles modification, and good photocatalytic activity toward organic pollutants. TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, [PMID:][10.1080/02772248.2020.1798448]
2.Yubin Xiang, Xue Lu, Jiangtao Yue, Yan Zhang, Xiaoyue Sun, Guilong Zhang, Dongqing Cai, Zhengyan Wu. (2020) Stimuli-responsive hydrogel as carrier for controlling the release and leaching behavior of hydrophilic pesticide. SCIENCE OF THE TOTAL ENVIRONMENT, 722 (137811). [PMID:32179301][10.1016/j.scitotenv.2020.137811]
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