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(S)-(-)-5-Fluorowillardiine - 98%, high purity , CAS No.140187-23-1, Agonist of GluA1;Agonist of GluA2;Agonist of GluA3;Agonist of GluA4
an extremely potent and selective AMPA receptor agonist at hGluR1 and hGluR2
Basic Description Synonyms (5S)-Fluorowillardiine | 5-Fluorowillardiine | J-007366 | KBio2_001794 | SR-01000597628-1 | EX-A4515 | F-205 | FWD | UNII-7CTR2LWV5M | (S)-F-Willardiine | 3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine | BRN 2299701 | (S)-5-FLUOROWILLARDII Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of GluA1;Agonist of GluA2;Agonist of GluA3;Agonist of GluA4 Product Description (S)-(-)-5-Fluorowillardiine is an extremely potent and selective AMPA receptor agonist at hGluR1 and hGluR2. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
Product Properties pKa pKₐ: 2.12 (Predicted), pKₐ: 9.6 (Predicted) Ki Data Glutamate receptor ionotropic, AMPA 1: Ki= 2.9 nM (rat); Glutamate receptor ionotropic, AMPA 2: Ki= 4 nM (rat); hGluR1: Ki= 14.7 nM; hGluR2 : Ki= 25.1 nM; hGluR5: Ki= 1.82 μM
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (2S)-2-amino-3-(5-fluoro-2,4-dioxopyrimidin-1-yl)propanoic acid INCHI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 InChi Key DBWPFHJYSTVBCZ-BYPYZUCNSA-N Canonical SMILES C1=C(C(=O)NC(=O)N1CC(C(=O)O)N)F Isomeric SMILES C1=C(C(=O)NC(=O)N1C[C@@H](C(=O)O)N)F PubChem CID 126569 Molecular Weight 217.15
Chemical and Physical Properties Solubility Soluble in 1.1eq. NaOH (50 mM), and water (partly). Refractive Index n20D1.60 (Predicted) Specific Rotation[α] α20/D -22°, c = 1 in 6N HCl Boil Point(°C) 529.21° C (Predicted) Melt Point(°C) 311.22° C (Predicted)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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I2222980