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(S)-(-)-Bay K 8644 - 98%, high purity , CAS No.98625-26-4, Activator of Ca v1.1;Activator of Ca v1.2;Activator of Ca v1.3;Activator of Ca v1.4
CaV1.x activator; (S)-(-)-enantiomer of(±)-Bay K 8644
Basic Description Synonyms (S)-BayK8644 | (S)-Bay-K-8644 | DTXSID50424954 | BBL101370 | CHEBI:93962 | (S)-(-)-Bay-K-8644 | D71053 | MFCD00008246 | BAY-K-8644-(s)-(-) | Bay-K-8644(S)-(-)- | (S)-(-)-BAY K 8644 | HY-15124 | methyl (4S)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms L-type Ca2+-channel activator with positive inotropic, vasoconstrictive and behavioral effectsin vivo.Racemateand(R)-(+)-Enantiomeralso available. Storage Temp Protected from light,Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ACTIVATOR Mechanism of action Activator of Ca v1.1;Activator of Ca v1.2;Activator of Ca v1.3;Activator of Ca v1.4 Product Description (S)-(-)-Bay K8644, a dihydropyridine compound is a Ca2+ channel activator.It is an enantiomer of Bay K 8644.
Application：
(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia in rats.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name methyl (4S)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate INCHI InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1 InChi Key ZFLWDHHVRRZMEI-ZDUSSCGKSA-N Canonical SMILES CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC Isomeric SMILES CC1=C([C@@H](C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC PubChem CID 6603728 Molecular Weight 356.30
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 35.63, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 35.63, Max Conc. mM: 100 Sensitivity Moisture sensitive; Light sensitive; Heat sensitive
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P264: Wash hands [and …] thoroughly after handling.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
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