Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C123671-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $89.90 | |
C123671-100mg | 100mg | In stock | $214.90 |
Aromatic L-amino acid decarboxylase inhibitor
Synonyms | (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid | (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methyl-propanoic acid | AS-16862 | carbidopa | HYDROCINNAMIC ACID, alpha-HYDRAZINO-3,4-DIHYDROXY-alpha-METHYL-, L- | SR-01000597655-5 | (S)-carbid |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism. |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of L-Aromatic amino-acid decarboxylase |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | ||
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | ||
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | ||
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | ||
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | ||
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens | ||
Vitamin D receptor agonist | AGONIST | ALA1977 | Vitamin D receptor | SINGLE PROTEIN | Homo sapiens |
IUPAC Name | (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid |
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INCHI | InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1 |
InChi Key | TZFNLOMSOLWIDK-JTQLQIEISA-N |
Canonical SMILES | CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN |
Isomeric SMILES | C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)NN |
WGK Germany | 3 |
PubChem CID | 34359 |
Molecular Weight | 226.23 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 4.52, Max Conc. mM: 20 |
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Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H351:Suspected of causing cancer H360:May damage fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
1. Shanying Han, Tianyu Du, Hui Jiang, Xuemei Wang. (2017) Synergistic effect of pyrroloquinoline quinone and graphene nano-interface for facile fabrication of sensitive NADH biosensor. BIOSENSORS & BIOELECTRONICS, 89 (422). [PMID:27156055] [10.1016/j.bios.2016.04.092] |
1. Waterhouse MJ, Chia YC, Lees GJ. (1979) Inhibition of human and rat hepatic aminotransferase activity with L-3,4-dihydroxyphenylalanine by inhibitors of peripheral aromatic amino acid decarboxylase.. Mol Pharmacol, 15 (1): (108-14). [PMID:423884] [10.1021/op500134e] |
2. Borri-Voltattorni C, Minelli A, Borri P. (1977) Interaction of L-alpha-methyl-alpha-hydrazino-3,4 dihydroxyphenylpropionic acid with dopa-decarboxylase from pig kidney.. FEBS Lett, 75 (1): (277-80). [PMID:852589] [10.1021/op500134e] |
3. Durso R, Evans JE, Josephs E, Szabo G, Evans B, Fernandez HH, Browne TR. (2000) Variable absorption of carbidopa affects both peripheral and central levodopa metabolism.. J Clin Pharmacol, 40 (8): (854-60). [PMID:10934669] [10.1021/op500134e] |
4. Ho CS, Butt A, Semra YK, Swaminathan R. (1997) Effect of carbidopa on the excretion of sodium, dopamine, and ouabain-like substance in the rat.. Hypertension, 30 (6): (1544-8). [PMID:9403580] [10.1021/op500134e] |
5. Shanying Han, Tianyu Du, Hui Jiang, Xuemei Wang. (2017) Synergistic effect of pyrroloquinoline quinone and graphene nano-interface for facile fabrication of sensitive NADH biosensor. BIOSENSORS & BIOELECTRONICS, 89 (422). [PMID:27156055] [10.1016/j.bios.2016.04.092] |