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(S)-dimetindene , CAS No.S613507, Antagonist of H 1 receptor;Antagonist of M 1 receptor;Antagonist of M 2 receptor;Antagonist of M 3 receptor;Antagonist of M 4 receptor;Antagonist of M 5 receptor

Item Number
S613507
Grouped product items
SKUSizeAvailabilityPrice Qty
S613507-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$700.90
S613507-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

Synonyms(+)-Dimethindene | (S)-dimetindene | GTPL10104 | UNII-41H5Y15VA0 | (S)-Dimethindene | 1H-Indene-2-ethanamine, N,N-dimethyl-3-((1S)-1-(2-pyridinyl)ethyl)- | 1H-Indene-2-ethanamine, N,N-dimethyl-3-(1-(2-pyridinyl)ethyl)-, (S)- | dimethindene-(S)-(+) | BDBM5
Specifications & PurityMoligand™
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of H 1 receptor;Antagonist of M 1 receptor;Antagonist of M 2 receptor;Antagonist of M 3 receptor;Antagonist of M 4 receptor;Antagonist of M 5 receptor

Associated Targets(Human)

CYP2C9 Tchem Cytochrome P450 2C9 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HRH1 Tclin Histamine H1 receptor (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM5 Tclin Muscarinic acetylcholine receptor M5 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM4 Tclin Muscarinic acetylcholine receptor M4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM4 Tclin Muscarinic acetylcholine receptor M4 (6041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM5 Tclin Muscarinic acetylcholine receptor M5 (4677 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Muscarinic acetylcholine receptor M2 antagonistANTAGONISTALA211Muscarinic acetylcholine receptor M2SINGLE PROTEINHomo sapiens

ISBN: [1]


PubMed: [1] , [2]


Wikipedia: [1]


Muscarinic acetylcholine receptor M2 antagonistANTAGONISTALA211Muscarinic acetylcholine receptor M2SINGLE PROTEINHomo sapiens

ISBN: [1]


PubMed: [1] , [2] , [3] , [4] , [5]


Muscarinic acetylcholine receptor M2 agonistAGONISTALA211Muscarinic acetylcholine receptor M2SINGLE PROTEINHomo sapiens

ISBN: [1]


PubMed: [1] , [2]


Wikipedia: [1]


Muscarinic acetylcholine receptor M2 antagonistANTAGONISTALA211Muscarinic acetylcholine receptor M2SINGLE PROTEINHomo sapiens

DailyMed: [1]


ISBN: [1]


PubMed: [1] , [2]


Muscarinic acetylcholine receptor M2 antagonistANTAGONISTALA211Muscarinic acetylcholine receptor M2SINGLE PROTEINHomo sapiens

DailyMed: [1]


PubMed: [1]


Muscarinic acetylcholine receptor M2 antagonistANTAGONISTALA211Muscarinic acetylcholine receptor M2SINGLE PROTEINHomo sapiens

FDA: [1]


ISBN: [1]


Wikipedia: [1]


Muscarinic acetylcholine receptor M2 antagonistANTAGONISTALA211Muscarinic acetylcholine receptor M2SINGLE PROTEINHomo sapiens

FDA: [1]


ISBN: [1]


Wikipedia: [1]


Muscarinic acetylcholine receptor M2 antagonistANTAGONISTALA211Muscarinic acetylcholine receptor M2SINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Muscarinic acetylcholine receptor M2 antagonistANTAGONISTALA211Muscarinic acetylcholine receptor M2SINGLE PROTEINHomo sapiens

ISBN: [1]


PubMed: [1] , [2] , [3] , [4]


Muscarinic acetylcholine receptor M2 antagonistANTAGONISTALA211Muscarinic acetylcholine receptor M2SINGLE PROTEINHomo sapiens

ISBN: [1]


PubMed: [1] , [2] , [3] , [4]


Names and Identifiers

IUPAC Name N,N-dimethyl-2-[3-[(1S)-1-pyridin-2-ylethyl]-1H-inden-2-yl]ethanamine
INCHI InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3/t15-/m1/s1
InChi Key MVMQESMQSYOVGV-OAHLLOKOSA-N
Canonical SMILES CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C
Isomeric SMILES C[C@H](C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C
PubChem CID 6604866

Certificates

C of A & Other Certificates

Related Documents

Solution Calculators