| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| S140886-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $43.90 | |
| S140886-5g | 5g | 2 | $93.90 | |
| S140886-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $169.90 | |
| S140886-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $380.90 | |
| S140886-100g | 100g | 3 | $1,370.90 | |
| S140886-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $6,167.90 |
Non-selective COX inhibitor
| Synonyms | Dexibuprofenum | Dexibuprofenum [INN-Latin] | (+)-(S)-Ibuprofen | AB00513957 | Prestwick1_000907 | S-(+)-ibuprofen | S(+)-Ibuprofen | UNII-671DKG7P5S | (S)-2-(4-Isobutylphenyl)propanoic acid | (S)-2-(4-Isobutylphenyl)propionic acid | (S)-2-(4-isobutyl-phe |
|---|---|
| Specifications & Purity | ≥98%(GC) |
| Biochemical and Physiological Mechanisms | Non-selective COX inhibitor (IC 50 values are 2.9 and 1.1 μM for COX1 and COX2, respectively). Non-steroidal anti-inflammatory drug (NSAID). Rapidly crosses the blood-brain barrier. |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Action Type | INHIBITOR |
| Mechanism of action | Cyclooxygenase inhibitor |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description | (S)-Ibuprofen is the active enantiomer of ibuprofen. (S)-Ibuprofen inhibits Cox-1 and Cox-2 with comparable potency (ID50 = 8.9-14 μM and 7.2-8.2 μM, respectively). (S)-Ibuprofen acts as a non-steroidal analgesic and antiinflammatory agent. This compound’s inhibition of Cox-1 and Cox-2 and activation of PPARα and PPARγ isoforms may be responsible for its pharmacological effects. (S)-(+)-Ibuprofen is the enantiomer associated with the anti-inflammatory action of ibuprofen, which is widely used as a nonsteroidal anti-inflammatory drug in racemic form. |
| ALogP | 3.5 |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Pubchem Sid | 504753594 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504753594 |
| IUPAC Name | (2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid |
| INCHI | InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1 |
| InChi Key | HEFNNWSXXWATRW-JTQLQIEISA-N |
| Canonical SMILES | CC(C)CC1=CC=C(C=C1)C(C)C(=O)O |
| Isomeric SMILES | C[C@@H](C1=CC=C(C=C1)CC(C)C)C(=O)O |
| WGK Germany | 3 |
| PubChem CID | 39912 |
| Molecular Weight | 206.28 |
| Beilstein | 3590022 |
| Reaxy-Rn | 3590020 |
Find and download the COA for your product by matching the lot number on the packaging.
5 results found
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 I2023088 | Certificate of Analysis | Jul 10, 2024 | S140886 |
| E1625043 | Certificate of Analysis | Jan 22, 2024 | S140886 |
| C1814106 | Certificate of Analysis | Jan 26, 2022 | S140886 |
| J2317128 | Certificate of Analysis | Nov 15, 2021 | S140886 |
| L2319078 | Certificate of Analysis | Nov 15, 2021 | S140886 |
| Solubility | Soluble in DMSO (100 mM), ethanol (100 mM), dichloromethane, ethyl acetate, and methanol. Insoluble in water. |
|---|---|
| Specific Rotation[α] | 59° |
| Flash Point(°F) | >235.4 °F |
| Flash Point(°C) | >113 °C |
| Melt Point(°C) | 49-53°C |
| Molecular Weight | 206.280 g/mol |
| XLogP3 | 3.500 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 4 |
| Exact Mass | 206.131 Da |
| Monoisotopic Mass | 206.131 Da |
| Topological Polar Surface Area | 37.300 Ų |
| Heavy Atom Count | 15 |
| Formal Charge | 0 |
| Complexity | 203.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| Pictogram(s) | GHS08, GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| Reaxy-Rn | 3590020 |
| 1. Dan Xiao, Ying Jin, Mengyu Zhang, Xiangjie Di, Lisha Fu, Changke Jiang, Zhuoli Lai, Yating Ge, Shanmian Ji, Yuming Zhang, Li Zheng, Zhenlei Wang, Fang Gong. (2023) Chiral pharmacokinetics of ibuprofen enantiomers in Chinese preterm neonates with patent ductus arteriosus using a validated UHPLC-MS/MS method. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1227 (123765). [PMID:37454407] [10.1016/j.jchromb.2023.123765] |
| 2. Zhenfei Wang, Bin Liang, Yanan Hou, Si Li, Li Xie, Liang Peng, Peng Zhang, Aijie Wang, Hui Yun, Xiangkai Li. (2022) Weak electrostimulation enhanced the microbial transformation of ibuprofen and naproxen. SCIENCE OF THE TOTAL ENVIRONMENT, 835 (155522). [PMID:35489501] [10.1016/j.scitotenv.2022.155522] |
| 3. Zefang Wang, Yan Peng, Chengjun Shi, Liping Wang, Xiaohong Chen, Wanwan Wu, Xu Wu, Yiming Zhu, Jingchen Zhang, Guiliang Cheng, Songlin Zhuang. (2021) Qualitative and quantitative recognition of chiral drugs based on terahertz spectroscopy. ANALYST, 146 (12): (3888-3898). [PMID:34042921] [10.1039/D1AN00500F] |
| 4. Qian Han, Cun Wang, Pingkun Liu, Gui Zhang, Li Song, Yingzi Fu. (2021) Achieving synergistically enhanced dual-mode electrochemiluminescent and electrochemical drug sensors via a multi-effect porphyrin-based metal-organic framework. SENSORS AND ACTUATORS B-CHEMICAL, 330 (129388). [PMID:] [10.1016/j.snb.2020.129388] |
| 5. Fang Wang, Bin Wang, Han Qu, Wenxing Zhao, Lei Duan, Yizhe Zhang, Yitong Zhou, Gang Yu. (2020) The influence of nanoplastics on the toxic effects, bioaccumulation, biodegradation and enantioselectivity of ibuprofen in freshwater algae Chlorella pyrenoidosa. ENVIRONMENTAL POLLUTION, 263 (114593). [PMID:32315820] [10.1016/j.envpol.2020.114593] |
| 6. Mingxia Liu, Lixia Chen, Tingting Tian, Zhiguo Zhang, Xiangjun Li. (2019) Identification and Quantitation of Enantiomers by Capillary Electrophoresis and Circular Dichroism Independent of Single Enantiomer Standard. ANALYTICAL CHEMISTRY, 91 (21): (13803–13809). [PMID:31591882] [10.1021/acs.analchem.9b03276] |
| 1. Dan Xiao, Ying Jin, Mengyu Zhang, Xiangjie Di, Lisha Fu, Changke Jiang, Zhuoli Lai, Yating Ge, Shanmian Ji, Yuming Zhang, Li Zheng, Zhenlei Wang, Fang Gong. (2023) Chiral pharmacokinetics of ibuprofen enantiomers in Chinese preterm neonates with patent ductus arteriosus using a validated UHPLC-MS/MS method. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1227 (123765). [PMID:37454407] [10.1016/j.jchromb.2023.123765] |
| 2. Zhenfei Wang, Bin Liang, Yanan Hou, Si Li, Li Xie, Liang Peng, Peng Zhang, Aijie Wang, Hui Yun, Xiangkai Li. (2022) Weak electrostimulation enhanced the microbial transformation of ibuprofen and naproxen. SCIENCE OF THE TOTAL ENVIRONMENT, 835 (155522). [PMID:35489501] [10.1016/j.scitotenv.2022.155522] |
| 3. Zefang Wang, Yan Peng, Chengjun Shi, Liping Wang, Xiaohong Chen, Wanwan Wu, Xu Wu, Yiming Zhu, Jingchen Zhang, Guiliang Cheng, Songlin Zhuang. (2021) Qualitative and quantitative recognition of chiral drugs based on terahertz spectroscopy. ANALYST, 146 (12): (3888-3898). [PMID:34042921] [10.1039/D1AN00500F] |
| 4. Qian Han, Cun Wang, Pingkun Liu, Gui Zhang, Li Song, Yingzi Fu. (2021) Achieving synergistically enhanced dual-mode electrochemiluminescent and electrochemical drug sensors via a multi-effect porphyrin-based metal-organic framework. SENSORS AND ACTUATORS B-CHEMICAL, 330 (129388). [PMID:] [10.1016/j.snb.2020.129388] |
| 5. Fang Wang, Bin Wang, Han Qu, Wenxing Zhao, Lei Duan, Yizhe Zhang, Yitong Zhou, Gang Yu. (2020) The influence of nanoplastics on the toxic effects, bioaccumulation, biodegradation and enantioselectivity of ibuprofen in freshwater algae Chlorella pyrenoidosa. ENVIRONMENTAL POLLUTION, 263 (114593). [PMID:32315820] [10.1016/j.envpol.2020.114593] |
| 6. Mingxia Liu, Lixia Chen, Tingting Tian, Zhiguo Zhang, Xiangjun Li. (2019) Identification and Quantitation of Enantiomers by Capillary Electrophoresis and Circular Dichroism Independent of Single Enantiomer Standard. ANALYTICAL CHEMISTRY, 91 (21): (13803–13809). [PMID:31591882] [10.1021/acs.analchem.9b03276] |
