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(S)-(+)-Ibuprofen - >98.0%(GC), high purity , Cyclooxygenase inhibitor, CAS No.51146-56-6, Cyclooxygenase inhibitor

≥98%(GC)

CAS#: 51146-56-6
Formula: (CH₃)₂CHCH₂C₆H₄CH(CH₃)CO₂H
Molecular Weight: 206.28
Beilstein Registry Number: 3590022
MDL number: MFCD00069289
PubChem CID: 39912

Item Number

S140886

Grouped product items
SKU	Size	Availability	Price
S140886-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$43.90
S140886-5g	5g	In stock	$93.90
S140886-10g	10g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$169.90
S140886-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$380.90
S140886-100g	100g	In stock	$1,370.90
S140886-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$6,167.90

Non-selective COX inhibitor

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Pharmaceutical ingredients

Basic Description

Synonyms	(S)-(+)-Ibuprofen\|DEXIBUPROFEN\|51146-56-6\|(S)-Ibuprofen\|(S)-2-(4-Isobutylphenyl)propanoic acid\|S(+)-Ibuprofen\|(S)-(+)-2-(4-Isobutylphenyl)propionic acid\|Seractil\|s-ibuprofen\|d-Ibuproten\|(+)-(S)-p-Isobutylhydratropic acid\|(S)-(+)-4-Isobutyl-alpha-methylphe
Specifications & Purity	>98.0%(GC)
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Cyclooxygenase inhibitor
Product Description	(S)-Ibuprofen is the active enantiomer of ibuprofen. (S)-Ibuprofen inhibits Cox-1 and Cox-2 with comparable potency (ID50 = 8.9-14 μM and 7.2-8.2 μM, respectively). (S)-Ibuprofen acts as a non-steroidal analgesic and antiinflammatory agent. This compound’s inhibition of Cox-1 and Cox-2 and activation of PPARα and PPARγ isoforms may be responsible for its pharmacological effects. (S)-(+)-Ibuprofen is the enantiomer associated with the anti-inflammatory action of ibuprofen, which is widely used as a nonsteroidal anti-inflammatory drug in racemic form. Enantiomeric form of the anti-inflammatory agent ibuprofen used in pharmacokinetic studies.

Associated Targets

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid
INCHI	InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1
InChi Key	HEFNNWSXXWATRW-JTQLQIEISA-N
Canonical SMILES	CC(C)CC1=CC=C(C=C1)C(C)C(=O)O
Isomeric SMILES	C[C@@H](C1=CC=C(C=C1)CC(C)C)C(=O)O
WGK Germany	3
PubChem CID	39912
Molecular Weight	206.28
Beilstein	3590022
Reaxy-Rn	3590020

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
I2023088	Certificate of Analysis	Jul 10, 2024	S140886
E1625043	Certificate of Analysis	Jan 22, 2024	S140886
J2317128	Certificate of Analysis	Nov 15, 2021	S140886
L2319078	Certificate of Analysis	Nov 15, 2021	S140886

Solubility

Soluble in DMSO (100 mM), ethanol (100 mM), dichloromethane, ethyl acetate, and methanol. Insoluble in water.

Specific Rotation[α]

59°

Flash Point(°F)

>235.4 °F

Flash Point(°C)

>113 °C

Melt Point(°C)

49-53°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
Reaxy-Rn	3590020

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