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(S)-N-[1-(3-morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide , CAS No.S613639, Activator of K v7.2;Activator of K v7.4;Activator of K v7.5
Basic Description
| Specifications & Purity | Moligand™ |
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| Grade | Moligand™ |
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| Action Type | ACTIVATOR |
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| Mechanism of action | Activator of K v7.2;Activator of K v7.4;Activator of K v7.5 |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | (E)-N-[(1S)-1-(3-morpholin-4-ylphenyl)ethyl]-3-phenylprop-2-enamide |
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| INCHI | InChI=1S/C21H24N2O2/c1-17(22-21(24)11-10-18-6-3-2-4-7-18)19-8-5-9-20(16-19)23-12-14-25-15-13-23/h2-11,16-17H,12-15H2,1H3,(H,22,24)/b11-10+/t17-/m0/s1 |
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| InChi Key | QMIMHUDEVKGOTQ-DVQDXYAYSA-N |
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| Canonical SMILES | O=C(N[C@H](c1cccc(c1)N1CCOCC1)C)/C=C/c1ccccc1 |
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| Isomeric SMILES | C[C@@H](C1=CC(=CC=C1)N2CCOCC2)NC(=O)/C=C/C3=CC=CC=C3 |
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| PubChem CID | 9949648 |
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References
| 1. Bentzen BH, Schmitt N, Calloe K, Dalby Brown W, Grunnet M, Olesen SP. (2006) The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.. Neuropharmacology, 51 (6): (1068-77). [PMID:16904708] [10.1021/op500134e] |
| 2. Wu YJ, Boissard CG, Greco C, Gribkoff VK, Harden DG, He H, L'Heureux A, Kang SH, Kinney GG, Knox RJ, Natale J, Newton AE, Lehtinen-Oboma S, Sinz MW, Sivarao DV, Starrett JE, Sun LQ, Tertyshnikova S, Thompson MW, Weaver D, Wong HS, Zhang L, Dworetzky SI. (2003) (S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.. J Med Chem, 46 (15): (3197-200). [PMID:12852750] [10.1021/op500134e] |
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