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S-(+)-Niguldipine hydrochloride , CAS No.113165-32-5, Antagonist of α 1A-adrenoceptor;Antagonist of α 1B-adrenoceptor;Antagonist of α 1D-adrenoceptor
a calcium channel protein inhibitor
Basic Description Synonyms NIGULDIPINE|S(+)-Niguldipine hydrochloride|113165-32-5|Niguldipine [INN]|(S)-Niguldipine|S(+)-niguldipine|Z81N45O25Z|5-O-[3-(4,4-diphenylpiperidin-1-yl)propyl] 3-O-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate|(-)-(S)-3- Storage Temp Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of α 1A-adrenoceptor;Antagonist of α 1B-adrenoceptor;Antagonist of α 1D-adrenoceptor Product Description S-(+)-Niguldipine hydrochloride is an L-type calcium channel protein inhibitor and α1A-AR adrenoceptor antagonist. S-(+)-Niguldipine hydrochloride is the more active enantiomer relative to (R)-(-)-Niguldipine hydrochloride .
Product Properties Ki Data α1A-AR: Ki= 0.16 nM (human); α1-1a adrenergic receptor: Ki= 0.38 nM (bovine); α1-1a adrenergic receptor: Ki= 6.38 nM (rat); Voltage-gated L-type calcium channel α1-1C subunit: Ki= 9 nM (rat); α1B-AR: Ki= 25.01 nM (human)
Names and Identifiers IUPAC Name 5-O-[3-(4,4-diphenylpiperidin-1-yl)propyl] 3-O-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate INCHI InChI=1S/C36H39N3O6/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3/t33-/m0/s1 InChi Key SVJMLYUFVDMUHP-XIFFEERXSA-N Canonical SMILES CC1=C(C(C(=C(N1)C)C(=O)OCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC Isomeric SMILES CC1=C([C@@H](C(=C(N1)C)C(=O)OCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC WGK Germany 3 PubChem CID 60602 Molecular Weight 646.18
Chemical and Physical Properties Solubility Soluble in DMSO (100 mM), ethanol (100 mM), and methanol (8 mg/ml). Insoluble in water, and dilute aqueous acid . Refractive Index n20D1.59 (Predicted) Specific Rotation[α] α22/D +14.62°, c = 0.13 in methanol; α20/D +14°, c = 1 in methanol Melt Point(°C) 135-137° C
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