Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
S136669-5mg | 5mg | In stock | $240.90 | |
S136669-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $686.90 |
NO donor
Synonyms | S-nitrosoglutathione|57564-91-7|gsno|SNOG|Nitrosoglutathione|Glutathione thionitrite|(S)-2-Amino-5-(((R)-1-((carboxymethyl)amino)-3-(nitrosothio)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid|N-(N-L-gamma-Glutamyl-S-nitroso-L-cysteinyl)glycine|S-NITROSO-L-G |
---|---|
Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | A carrier of nitric oxide. Breaks down at physiological pH to produce nitric oxide. Relaxes smooth muscle and inhibits platelet aggregation. |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Note | Unstable; make up solutions fresh and use immediately. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | S-Nitrosoglutathione (GSNO) is an endogenous nitrogen oxide and is highly distributed in extracellular fluids of the lung and brain. S-Nitrosoglutathione (GSNO), an amino acid nitric oxide donor, when under physiological conditions spontaneously releases nitric oxide. In research it has been observed to selectively inhibit platelet activation and display cardioprotective effects. This product also inhibits NF-κB activation, endothelial cell proliferation and cathepsin B (cysteine proteases). GNSO has demonstrated dose dependent effects on Thymocytes by inducing apoptosis in T cells in low concentrations (< 0.6 mM), while protecting T cells from apoptosis in higher concentrations (1-2 mM). S-Nitrosoglutathione (GSNO) has been used: • as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD). • as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay. A spontaneously releasing nitric oxide donor which inhibits NFκB and platelet activation. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
IUPAC Name | (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-nitrososulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid |
---|---|
INCHI | InChI=1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1 |
InChi Key | HYHSBSXUHZOYLX-WDSKDSINSA-N |
Canonical SMILES | C(CC(=O)NC(CSN=O)C(=O)NCC(=O)O)C(C(=O)O)N |
Isomeric SMILES | C(CC(=O)N[C@@H](CSN=O)C(=O)NCC(=O)O)[C@@H](C(=O)O)N |
WGK Germany | 3 |
RTECS | MC0558000 |
PubChem CID | 104858 |
Molecular Weight | 336.32 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L2308337 | Certificate of Analysis | Dec 05, 2023 | S136669 |
L2308338 | Certificate of Analysis | Dec 05, 2023 | S136669 |
J2111538 | Certificate of Analysis | Jul 10, 2023 | S136669 |
B2323426 | Certificate of Analysis | Feb 03, 2023 | S136669 |
B2323427 | Certificate of Analysis | Feb 03, 2023 | S136669 |
H2210010 | Certificate of Analysis | Jun 25, 2022 | S136669 |
H2210011 | Certificate of Analysis | Jun 25, 2022 | S136669 |
Solubility | Soluble in water (25 mg/ml), DMSO (20 mg/ml), and PBS. Insoluble in 100% ethanol, methanol, and DMF. |
---|
Pictogram(s) | GHS07 |
---|---|
Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | MC0558000 |