A carrier of nitric oxide. Breaks down at physiological pH to produce nitric oxide. Relaxes smooth muscle and inhibits platelet aggregation.
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Note
Unstable; make up solutions fresh and use immediately. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
S-Nitrosoglutathione (GSNO) is an endogenous nitrogen oxide and is highly distributed in extracellular fluids of the lung and brain.
S-Nitrosoglutathione (GSNO), an amino acid nitric oxide donor, when under physiological conditions spontaneously releases nitric oxide. In research it has been observed to selectively inhibit platelet activation and display cardioprotective effects. This product also inhibits NF-κB activation, endothelial cell proliferation and cathepsin B (cysteine proteases). GNSO has demonstrated dose dependent effects on Thymocytes by inducing apoptosis in T cells in low concentrations (< 0.6 mM), while protecting T cells from apoptosis in higher concentrations (1-2 mM).
S-Nitrosoglutathione (GSNO) has been used:
• as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD).
• as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay.
A spontaneously releasing nitric oxide donor which inhibits NFκB and platelet activation.
2.Ying Zhang, Tianfu Zhou, Jian Li, Nuo Xu, Mingze Cai, Hong Zhang, Qinfu Zhao, Siling Wang. (2023) Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy. International Journal of Nanomedicine, [PMID:33824588][10.2147/IJN.S270466]
3.Jianwen Zhang, Xianlan Ke, Maotao Huang, Xinyu Pei, Shuai Gao, Dimeng Wu, Junying Chen, Yajun Weng. (2022) NO released via both a Cu-MOF-based donor and surface-catalyzed generation enhances anticoagulation and antibacterial surface effects. Biomaterials Science, 11 (1):(322-338). [PMID:36448996][10.1039/D2BM01515C]
4.Yue Xu, Xia Jiang, Chuan Niu, Shaojie Yang, Xiong Xiao, Ziwei Huang, Li Feng. (2022) Preparation and Assessment of Nitric Oxide-Releasing Small-Diameter Collagen-Based Vascular Graft for Vascular Regeneration Applications. MACROMOLECULAR MATERIALS AND ENGINEERING, 307 (7):(2100862). [PMID:][10.1002/mame.202100862]
2.Ying Zhang, Tianfu Zhou, Jian Li, Nuo Xu, Mingze Cai, Hong Zhang, Qinfu Zhao, Siling Wang. (2023) Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy. International Journal of Nanomedicine, [PMID:33824588][10.2147/IJN.S270466]
3.Jianwen Zhang, Xianlan Ke, Maotao Huang, Xinyu Pei, Shuai Gao, Dimeng Wu, Junying Chen, Yajun Weng. (2022) NO released via both a Cu-MOF-based donor and surface-catalyzed generation enhances anticoagulation and antibacterial surface effects. Biomaterials Science, 11 (1):(322-338). [PMID:36448996][10.1039/D2BM01515C]
4.Yue Xu, Xia Jiang, Chuan Niu, Shaojie Yang, Xiong Xiao, Ziwei Huang, Li Feng. (2022) Preparation and Assessment of Nitric Oxide-Releasing Small-Diameter Collagen-Based Vascular Graft for Vascular Regeneration Applications. MACROMOLECULAR MATERIALS AND ENGINEERING, 307 (7):(2100862). [PMID:][10.1002/mame.202100862]
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L2308337