S- (+)-Rolipram - ≥99%, high purity , CAS No.85416-73-5

  • ≥99%
Item Number
S129683
Grouped product items
SKUSizeAvailabilityPrice Qty
S129683-5mg
5mg
In stock
$70.90
S129683-10mg
10mg
In stock
$117.90
S129683-25mg
25mg
In stock
$265.90
S129683-50mg
50mg
In stock
$459.90
S129683-100mg
100mg
In stock
$810.90

PDE4 inhibitor; less active enantiomer

Basic Description

SynonymsF13078 | C2086 | EN300-7869230 | H6G4VMQ24K | S- (+)-Rolipram | S-rolipram | W-109097 | NCGC00381709-04 | MLS006011228 | AS-56538 | BDBM50042056 | CHEBI:59540 | HB2897 | NCGC00381709-02 | 2,6-Dimethyl-meta-dioxan-4-yl acetate | Rolipram, (+)- | MFCD030938
Specifications & Purity≥99%
Biochemical and Physiological MechanismsPDE4 inhibitor (IC 50 = 0.58 μM). Less active enantiomer.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4 (3344 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Zika virus (1028 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
INCHI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
InChi Key HJORMJIFDVBMOB-GFCCVEGCSA-N
Canonical SMILES COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
Isomeric SMILES COC1=C(C=C(C=C1)[C@@H]2CC(=O)NC2)OC3CCCC3
PubChem CID 158758
Molecular Weight 275.34
Reaxy-Rn 6687797

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
I2227591Certificate of AnalysisJul 10, 2024 S129683
I2227593Certificate of AnalysisJul 10, 2024 S129683
I2227597Certificate of AnalysisJul 10, 2024 S129683
I2227628Certificate of AnalysisJul 10, 2024 S129683
I2227627Certificate of AnalysisJul 09, 2024 S129683

Chemical and Physical Properties

SolubilityDMSO 55 mg/mL Water <1 mg/mL Ethanol 55 mg/mL
SensitivityHeat Sensitive
Specific Rotation[α]32° (C=0.5,MeOH)
Melt Point(°C)134 °C

Safety and Hazards(GHS)

Reaxy-Rn 6687797

Related Documents

References

1. Blazon M et al..  (2021)  N-type calcium channels control GABAergic transmission in brain areas related to fear and anxiety..  OBM Neurobiol,    [PMID:33521586]

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