Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T107322-20mg | 20mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $9.90 | |
T107322-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $27.90 | |
T107322-200mg | 200mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $43.90 | |
T107322-500mg | 500mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $104.90 | |
T107322-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $166.90 |
Calcium channel blocker. Anti-inflammatory and antitumor agent.
Synonyms | tetrandrine | 518-34-3 | D-Tetrandrine | (+)-Tetrandrine | Tetrandrin | Fanchinine | Sinomenine A | (S,S)-Tetrandrine | Hanfangchin A | hanjisong | DL-Tetrandine | NSC-77037 | NSC 77037 | (+-)-Tetrandine | (S,S)-(+)-Tetrandrine | d-Tetrandr | CHEBI:49 | 23495-89-8 | (+/-)-Tetrandrine | S,S-(+ |
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Specifications & Purity | Moligand™, analytical standard, ≥98%(HPLC), for food analysis |
Biochemical and Physiological Mechanisms | Calcium channel blocker. (IC 50 values are 8 and 20 µM for L -type and T-type calcium channels respectively). Various pharmacological effects. Shows anti-inflammatory and antitumor activity. Inhibits osteoclast differentiation in vivo. |
Shipped In | Normal |
Grade | analytical standard, Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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IUPAC Name | (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene |
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INCHI | InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1 |
InChi Key | WVTKBKWTSCPRNU-KYJUHHDHSA-N |
Canonical SMILES | CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC |
Isomeric SMILES | CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC |
WGK Germany | 3 |
RTECS | XE9350000 |
PubChem CID | 73078 |
Molecular Weight | 622.75 |
Beilstein | 877811 |
Reaxy-Rn | 79006 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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K2110174 | Certificate of Analysis | Aug 02, 2023 | T107322 |
K2110175 | Certificate of Analysis | Aug 02, 2023 | T107322 |
K2110212 | Certificate of Analysis | Aug 02, 2023 | T107322 |
B2303942 | Certificate of Analysis | Feb 10, 2023 | T107322 |
Melt Point(°C) | 219-222°C |
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Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H302:Harmful if swallowed H300:Fatal if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RTECS | XE9350000 |
Reaxy-Rn | 79006 |
1. Qing Wang,Jie Chen,Kun Huang,Xin Zhang,Li Xu,Zhi-guo Shi. (2014-12-07) Preparation, characterization and application of N-methylene phosphonic acid chitosan grafted magnesia-zirconia stationary phase.. Analytica chimica acta, 854 (191-201). [PMID:25479884] |
2. Liyun Ma,Si-Min Liu,Lin Yao,Li Xu. (2014-12-22) Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica.. Journal of chromatography. A, 1376 (64-73). [PMID:25528071] |
1. King VF, Garcia ML, Himmel D, Reuben JP, Lam YK, Pan JX, Han GQ, Kaczorowski GJ. (1988) Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin.. J Biol Chem, 263 (5): (2238-44). [PMID:2448307] |
2. Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA. (2015) Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.. Science, 347 (6225): (995-8). [PMID:25722412] |
3. Heister PM, Poston RN. (2020) Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID-19.. Pharmacol Res Perspect, 8 (5): (e00653). [PMID:32930523] |
4. Sun J, Song P, Wang Y, Chen Y. (2019) Clinical efficacy of acetylcysteine combined with tetrandrine tablets in the treatment of silicosis and the effect on serum IL-6 and TNF-α.. Exp Ther Med, 18 (5): (3383-3388). [PMID:31602212] |
5. Freeman SA et al.. (2020) Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance.. Science, 367 (6475): (301-305). [PMID:31806695] |
6. Hoffmann M et al.. (2016) The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent.. PLoS One, 11 (2): (e0149651). [PMID:26901159] |
7. Qing Wang,Jie Chen,Kun Huang,Xin Zhang,Li Xu,Zhi-guo Shi. (2014-12-07) Preparation, characterization and application of N-methylene phosphonic acid chitosan grafted magnesia-zirconia stationary phase.. Analytica chimica acta, 854 (191-201). [PMID:25479884] |
8. Liyun Ma,Si-Min Liu,Lin Yao,Li Xu. (2014-12-22) Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica.. Journal of chromatography. A, 1376 (64-73). [PMID:25528071] |