Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

(S)-SLV 319 - ≥98%, high purity , Cannabinoid CB1 receptor antagonist, CAS No.464213-10-3, Cannabinoid CB1 receptor antagonist

Item Number
S335814
Grouped product items
SKUSizeAvailabilityPrice Qty
S335814-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$87.90
S335814-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$295.90

a potent, selective CB1 receptor antagonist

Basic Description

SynonymsGTPL9234 | SR-01000946296 | JD 5001 | (S)-(-)-3-(4-chlorophenyl)-N'-(4-chlorophenylsulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide | (S)-SLV 319 | (S,E)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionCannabinoid CB1 receptor antagonist
Product Description

(S)-SLV 319 is a potent and selective CB1 receptor antagonist (K|i|= 7.8) with much weaker effects on CB2 (K|i|= 7,943 nM). (S)-SLV 319 is more water soluble than other known CB1 receptor ligands due to its less lipophilic nature.

Product Properties

ALogP5.3

Associated Targets(Human)

CNR1 Tclin Cannabinoid receptor 1 (15 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CNR2 Tchem Cannabinoid receptor 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR2 Tchem Cannabinoid CB2 receptor (16942 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Cannabinoid CB1 receptor agonistAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

DailyMed: [1]


Cannabinoid CB1 receptor agonistAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

DailyMed: [1]


PubMed: [1]


Cannabinoid CB1 receptor agonistAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Cannabinoid CB1 receptor antagonistANTAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Cannabinoid CB1 receptor antagonistANTAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

Other: [1]


Cannabinoid CB1 receptor antagonistANTAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Wikipedia: [1]


Cannabinoid CB1 receptor antagonistANTAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Cannabinoid CB1 receptor agonistAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Wikipedia: [1]


Cannabinoid CB1 receptor antagonistANTAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Cannabinoid CB1 receptor inverse agonistINVERSE AGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Names and Identifiers

IUPAC Name (4S)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
INCHI InChI=1S/C23H20Cl2N4O2S/c1-26-23(28-32(30,31)20-13-11-19(25)12-14-20)29-15-21(16-5-3-2-4-6-16)22(27-29)17-7-9-18(24)10-8-17/h2-14,21H,15H2,1H3,(H,26,28)/t21-/m1/s1
InChi Key AXJQVVLKUYCICH-OAQYLSRUSA-N
Canonical SMILES CN=C(NS(=O)(=O)C1=CC=C(C=C1)Cl)N2CC(C(=N2)C3=CC=C(C=C3)Cl)C4=CC=CC=C4
Isomeric SMILES CN=C(NS(=O)(=O)C1=CC=C(C=C1)Cl)N2C[C@@H](C(=N2)C3=CC=C(C=C3)Cl)C4=CC=CC=C4
PubChem CID 9826744
Molecular Weight 487.4

Certificates

C of A & Other Certificates

Chemical and Physical Properties

Melt Point(°C)173-174° C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

References

1. Lange JH, Coolen HK, van Stuivenberg HH, Dijksman JA, Herremans AH, Ronken E, Keizer HG, Tipker K, McCreary AC, Veerman W et al..  (2004)  Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists..  J Med Chem,  47  (3): (627-43).  [PMID:14736243] [10.1021/op500134e]

Solution Calculators