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(S)-SNAP 5114 - ≥98%(HPLC), high purity , CAS No.157604-55-2, Inhibitor of GAT2;Inhibitor of GAT3
Basic Description Synonyms 157604-55-2 | SNAP-5114 | (S)-SNAP 5114 | (S)-SNAP5114 | (S)-SNAP-5114 | CHEMBL75035 | (3S)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid | (S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid | 3-Piperidinecarboxylic acid, 1- Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50values are 5, 21 and 388μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administrationin vivo. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of GAT2;Inhibitor of GAT3 Product Description Product description：
(S)-SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant drug.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name (3S)-1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid INCHI InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1 InChi Key VDLDUZLDZBVOAS-QFIPXVFZSA-N Canonical SMILES COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)OCCN4CCCC(C4)C(=O)O Isomeric SMILES COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)OCCN4CCC[C@@H](C4)C(=O)O WGK Germany 3 PubChem CID 10458835 Molecular Weight 505.61
Chemical and Physical Properties Solubility Solvent:ethanol, Max Conc. mg/mL: 25.28, Max Conc. mM: 50; Solvent:DMSO, Max Conc. mg/mL: 50.56, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 RIDADR NONHforallmodesoftransport
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