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S-Trityl-L-cysteine - 10mM in DMSO, high purity , CAS No.2799-07-7
Potent, cell-permeable kinesin Eg5 inhibitor
Basic Description Synonyms S-Trityl-L-cysteine | 2799-07-7 | H-Cys(Trt)-OH | (+)-S-Trityl-L-cysteine | S-Tritylcysteine | Tritylcysteine | NSC 83265 | S-(Triphenylmethyl)-L-cysteine | 3-Tritylthio-L-alanine | STLC | Alanine, 3-(tritylthio)-, L- | (R)-2-amino-3-(tritylthio)propanoic acid | (2R)-2-amino-3-[ Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Potent, cell-permeable kinesin Eg5 inhibitor (IC 50 = 140 nM). Blocks mitotic spindles and induces mitotic arrest in vitro . Antitumor and antimitotic agent. Active in vivo and in vitro . Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description (+)-S-Trityl-L-cysteine, a non-natural, sulfur-containing amino acid is commonly used as a reagent in solution phase peptide synthesis (SPPS). It is also used as a metal-binding agent to synthesize substituted ferrocenoyl peptide conjugates using HBTU peptide coupling reagent for the cation-sensing applications solution via peptide-metal interactions.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (2R)-2-amino-3-tritylsulfanylpropanoic acid INCHI InChI=1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1 InChi Key DLMYFMLKORXJPO-FQEVSTJZSA-N Canonical SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)SCC(C(=O)O)N Isomeric SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)SC[C@@H](C(=O)O)N WGK Germany 3 RTECS AY7710000 PubChem CID 76044 Molecular Weight 363.47 Beilstein 2339626 Reaxy-Rn 2339626
Chemical and Physical Properties Specific Rotation[α] 111 ° (C=0.8, 0.04mol Ethanolic HCl) Melt Point(°C) 182-183°C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
WGK Germany 3 RTECS AY7710000 Reaxy-Rn 2339626
Citations of This Product 1. Zhanpeng Ren, Jianying Wang, Chenglong Xue, Minghua Deng, Haiyang Yu, Tianci Lin, Jiayuan Zheng, Rongxiang He, Xianbao Wang, Jinhua Li. (2023) Ultrahighly Sensitive and Selective Glutathione Sensor Based on Carbon Dot-Functionalized Solution-Gate Graphene Transistor. ANALYTICAL CHEMISTRY, 95 (48): (17750–17758). [PMID:37971943 ] [10.1021/acs.analchem.3c03656 ]
References 1. Zhanpeng Ren, Jianying Wang, Chenglong Xue, Minghua Deng, Haiyang Yu, Tianci Lin, Jiayuan Zheng, Rongxiang He, Xianbao Wang, Jinhua Li. (2023) Ultrahighly Sensitive and Selective Glutathione Sensor Based on Carbon Dot-Functionalized Solution-Gate Graphene Transistor. ANALYTICAL CHEMISTRY, 95 (48): (17750–17758). [PMID:37971943 ] [10.1021/acs.analchem.3c03656 ]
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