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G protein-coupled receptors (GPCRs)
Neuropeptide Y receptors
(S)-VU0637120 , CAS No.1214099-39-4, Allosteric modulator of Y 4 receptor

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(S)-VU0637120 , CAS No.1214099-39-4, Allosteric modulator of Y 4 receptor

Moligand™

CAS#: 1214099-39-4
PubChem CID: 44086933

Item Number

S614273

Grouped product items
SKU	Size	Availability	Price	Qty
S614273-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
S614273-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

Y4 receptor Allosteric modulator

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of Y 4 receptor

Associated Targets(Human)

NPY4R Tchem Neuropeptide Y receptor type 4 (0 Activities)

Discover Target: NPY4R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NPY4R Tchem Neuropeptide Y receptor type 4 (1071 Activities)

Discover Target: NPY4R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NPY2R Tchem Neuropeptide Y receptor type 2 (3731 Activities)

Discover Target: NPY2R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NPY5R Tchem Neuropeptide Y receptor type 5 (1834 Activities)

Discover Target: NPY5R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Npy1r Neuropeptide Y receptor type 1 (8 Activities)

Discover Target: Npy1r

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N-(6,7-dihydro-[1,4]dioxino[2,3-f][1,3]benzothiazol-2-yl)-1-methylsulfonylpiperidine-2-carboxamide
INCHI	InChI=1S/C16H19N3O5S2/c1-26(21,22)19-5-3-2-4-11(19)15(20)18-16-17-10-8-12-13(9-14(10)25-16)24-7-6-23-12/h8-9,11H,2-7H2,1H3,(H,17,18,20)
InChi Key	XLSQVBRMGFLMGL-UHFFFAOYSA-N
Canonical SMILES	CS(=O)(=O)N1CCCCC1C(=O)NC2=NC3=CC4=C(C=C3S2)OCCO4
Isomeric SMILES	CS(=O)(=O)N1CCCCC1C(=O)NC2=NC3=CC4=C(C=C3S2)OCCO4
PubChem CID	44086933

Database links

PubChem CID	44086933
ChEMBL Ligand	CHEMBL4780125
BindingDB Ligand	50563420
CAS Registry No.	1214099-39-4

Certificates

Certificate of Analysis(COA)

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References

1. Schüß C, Vu O, Schubert M, Du Y, Mishra NM, Tough IR, Stichel J, Weaver CD, Emmitte KA, Cox HM et al.. (2021) Highly Selective Y₄ Receptor Antagonist Binds in an Allosteric Binding Pocket.. J Med Chem, 64 (5): (2801-2814). [PMID:33595306] [10.1021/op500134e]

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