Basic Description

Synonyms	Fema No. 4725 \| 1P43YY1KO2 \| 1119831-25-2 \| UNII-1P43YY1KO2 \| 3-(1-((3,5-Dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)-imidazolidine-2,4-dione \| 2,4-Imidazolidinedione, 3-(1-((3,5-dimethyl-4-isoxazolyl)-methyl)-1H-pyrazol-4-yl)-1-((3-hydroxyphe
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of TAS2R8

Associated Targets(Human)

TAS2R8 Tchem Taste receptor type 2 member 8 (3 Activities)

Discover Target: TAS2R8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Homo sapiens (32628 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R31 Tchem Taste receptor type 2 member 31 (86 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R14 Tchem Taste receptor type 2 member 14 (240 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R16 Tchem Taste receptor type 2 member 16 (102 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R4 Tchem Taste receptor type 2 member 4 (14 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R41 Tchem Taste receptor type 2 member 41 (57 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R9 Tchem Taste receptor type 2 member 9 (14 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R50 Tchem Taste receptor type 2 member 50 (12 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R8 Tchem Taste receptor type 2 member 8 (387 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R39 Tchem Taste receptor type 2 member 39 (48 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R43 Tchem Taste receptor type 2 member 43 (15 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R30 Tchem Taste receptor type 2 member 30 (12 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R13 Tchem Taste receptor type 2 member 13 (13 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R7 Tchem Taste receptor type 2 member 7 (31 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R5 Tchem Taste receptor type 2 member 5 (11 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R3 Tchem Taste receptor type 2 member 3 (12 Activities)

Discover Target: TAS2R3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-1-[(3-hydroxyphenyl)methyl]imidazolidine-2,4-dione
INCHI	InChI=1S/C19H19N5O4/c1-12-17(13(2)28-21-12)10-23-9-15(7-20-23)24-18(26)11-22(19(24)27)8-14-4-3-5-16(25)6-14/h3-7,9,25H,8,10-11H2,1-2H3
InChi Key	LLJBKECMPVCSDS-UHFFFAOYSA-N
Canonical SMILES	CC1=NOC(C)=C1CN2C=C(C=N2)N3C(=O)CN(CC4=CC=CC(O)=C4)C3=O
Isomeric SMILES	CC1=C(C(=NO1)C)CN2C=C(C=N2)N3C(=O)CN(C3=O)CC4=CC(=CC=C4)O
PubChem CID	57422431

Database links

PubChem CID	57422431
ChEMBL Ligand	CHEMBL3924866
BindingDB Ligand	211262

Certificates

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References

1. Fotsing JR, Darmohusodo V, Patron AP, Ching BW, Brady T, Arellano M, Chen Q, Davis TJ, Liu H, Servant G et al.. (2020) Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists.. J Med Chem, 63 (9): (4957-4977). [PMID:32330040] [10.1021/op500134e]

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SKU	Size	Availability	Price	Qty
S613385-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90
S613385-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

S6821 , CAS No.S613385, Antagonist of TAS2R8