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Sabutoclax - ≥96%, high purity , CAS No.1228108-65-3
Basic Description Synonyms 39Y89ZRK34 | 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis((R)-2-phenylpropyl)-[2,2'-binaphthalene]-5,5'-dicarboxamide | HY-15191 | UNII-39Y89ZRK34 | BDBM50316672 | (1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-[2,2'- Specifications & Purity Moligand™, ≥96% Storage Temp Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Grade Moligand™ Product Description Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2,3,5-trihydroxy-7-methyl-N-[(2R)-2-phenylpropyl]-6-[1,6,7-trihydroxy-3-methyl-5-[[(2R)-2-phenylpropyl]carbamoyl]naphthalen-2-yl]naphthalene-1-carboxamide INCHI InChI=1S/C42H40N2O8/c1-21-15-27-29(17-31(45)39(49)35(27)41(51)43-19-23(3)25-11-7-5-8-12-25)37(47)33(21)34-22(2)16-28-30(38(34)48)18-32(46)40(50)36(28)42(52)44-20-24(4)26-13-9-6-10-14-26/h5-18,23-24,45-50H,19-20H2,1-4H3,(H,43,51)(H,44,52)/t23-,24-/m0/s1 InChi Key RAYNZUHYMMLQQA-ZEQRLZLVSA-N Canonical SMILES CC1=CC2=C(C(=C(C=C2C(=C1C3=C(C4=CC(=C(C(=C4C=C3C)C(=O)NCC(C)C5=CC=CC=C5)O)O)O)O)O)O)C(=O)NCC(C)C6=CC=CC=C6 Isomeric SMILES CC1=CC2=C(C(=C(C=C2C(=C1C3=C(C4=CC(=C(C(=C4C=C3C)C(=O)NC[C@H](C)C5=CC=CC=C5)O)O)O)O)O)O)C(=O)NC[C@H](C)C6=CC=CC=C6 Alternate CAS 1228108-65-3 PubChem CID 46236925 MeSH Entry Terms 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide;BI 97C1;BI-97C1;Sabutoclax Molecular Weight 700.8
Chemical and Physical Properties Solubility Soluble in DMSO to 100 mM and in ethanol to 50 mM (with warming)
References 1. Wei J, Stebbins JL, Kitada S, Dash R, Placzek W, Rega MF, Wu B, Cellitti J, Zhai D, Yang L et al. . (2010) BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.. J Med Chem, 53 (10): (4166-76). [PMID:20443627 ] [10.1021/op500134e ]
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