Skip to the beginning of the images gallery

Sacituzumab govitecan (anti-TROP2) - Primary antibody, specific to TACSTD2, >90% (SDS-PAGE&SEC), high purity, Human IgG1, Antibody of tumor associated calcium signal transducer 2

≥90%(SDS-PAGE&SEC)
Lot by Lot

Features and benefits

Short Overview:
Purity>90% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Conjugated (Mc-VC-PAB-SN38)
Species reactivity(Reacts with): Cynomolgus monkey,Human
Isotype: Human IgG1

Application:

Animal Model
ELISA
Flow Cytometry
Functional Assay

Item Number

Ab175650

Grouped product items
SKU	Size	Availability	Price
Ab175650-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$79.90
Ab175650-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$379.90
Ab175650-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$949.90
Ab175650-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,519.90

Purity>90% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Conjugated (Mc-VC-PAB-SN38)

View related series

Click to view target information: TACSTD2

Accession#:P09758 Gene ID:4070 TACSTD2 TROP2

Basic Description

Product Name	Sacituzumab govitecan (anti-TROP2) - Primary antibody, specific to TACSTD2, >90% (SDS-PAGE&SEC), high purity, Human IgG1
Synonyms	Cell surface glycoprotein Trop 2 antibody \| Cell surface glycoprotein Trop-2 antibody \| Cell surface glycoprotein Trop2 antibody \| Epithelial glycoprotein 1 antibody \| GA733 1 antibody \| GA7331 antibody \| M1S 1 antibody \| M1S1 antibody \| Membrane componen
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥90%(SDS-PAGE&SEC), Lot by Lot
Specificity	TACSTD2
Conjugation	Mc-VC-PAB-SN38
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	BINDING AGENT
Mechanism of action	Antibody of tumor associated calcium signal transducer 2
Product Description	Sacituzumab govitecan (anti-TROP2) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan (anti-TROP2) shows anticancer activity. Purity >90% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg

Product Properties

Isotype	Human IgG1
Light Chain Type	kappa
SDS-PAGE	145 kDa
Purification Method	Protein A purified
Purity	>90% (SDS-PAGE&SEC)
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	1491917-83-9

Associated Targets(Human)

TACSTD2 Tclin Tumor-associated calcium signal transducer 2 (0 Activities)

Discover Target: TACSTD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TACSTD2 Tclin Tumor-associated calcium signal transducer 2 (0 Activities)

Discover Target: TACSTD2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

References

1. Stoyanova T, Goldstein AS, Cai H, Drake JM, Huang J, Witte ON. (2012) Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling.. Genes Dev, 26 (20): (2271-85). [PMID:23070813]
2. Ocean AJ, Starodub AN, Bardia A, Vahdat LT, Isakoff SJ, Guarino M, Messersmith WA, Picozzi VJ, Mayer IA, Wegener WA et al.. (2017) Sacituzumab govitecan (IMMU-132), an anti-Trop-2-SN-38 antibody-drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics.. Cancer, 123 (19): (3843-3854). [PMID:28558150]
3. Sahota S, Vahdat LT. (2017) Sacituzumab govitecan: an antibody-drug conjugate.. Expert Opin Biol Ther, 17 (8): (1027-1031). [PMID:28503956]
4. Stein R, Basu A, Goldenberg DM, Lloyd KO, Mattes MJ. (1994) Characterization of cluster 13: the epithelial/carcinoma antigen recognized by MAb RS7.. Int J Cancer Suppl, 8 (3): (98-102). [PMID:8194903]
5. Stein R, Basu A, Chen S, Shih LB, Goldenberg DM. (1993) Specificity and properties of MAb RS7-3G11 and the antigen defined by this pancarcinoma monoclonal antibody.. Int J Cancer, 55 (6): (938-46). [PMID:8253531]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Sacituzumab govitecan (anti-TROP2) - Primary antibody, specific to TACSTD2, >90% (SDS-PAGE&SEC), high purity, Human IgG1, Antibody of tumor associated calcium signal transducer 2

Basic Description

Product Properties

Associated Targets(Human)

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator