SAFit1 - 99%, high purity , CAS No.1643125-32-9

Item Number

S648365

Grouped product items
SKU	Size	Availability	Price
S648365-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$450.90
S648365-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$650.90
S648365-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
S648365-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,200.90

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Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	SAFit1 is a FK506 binding protein 51 ( FKBP51 )-specific inhibitor with a K i of 4±0.3 nM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	SAFit1 is a FK506 binding protein 51 ( FKBP51 )-specific inhibitor with a K i of 4±0.3 nM In Vitro SAFit1 (1-1000 nM) potently stimulates neurite outgrowth in two neuronal cell lines (N2a and SH-SY5Y) as well as in primary hippocampal neurons. SAFit1 is active over a wide concentration range. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 4±0.3 nM (FKBP51), >50000 nM (FKBP52)

Associated Targets(Human)

FKBP1A Tclin Peptidyl-prolyl cis-trans isomerase FKBP1A (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FKBP5 Tchem Peptidyl-prolyl cis-trans isomerase FKBP5 (3 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FKBP1A Tclin FK506-binding protein 1A (1014 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FKBP4 Tchem FK506 binding protein 4 (257 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KB (17409 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FKBP5 Tchem Peptidyl-prolyl cis-trans isomerase FKBP5 (259 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-[3-[(1R)-1-[(2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
INCHI	InChI=1S/C42H53NO11/c1-48-34-20-18-27(22-35(34)49-2)17-19-33(29-14-11-15-31(23-29)53-26-38(44)45)54-42(47)32-16-9-10-21-43(32)41(46)39(28-12-7-6-8-13-28)30-24-36(50-3)40(52-5)37(25-30)51-4/h11,14-15,18,20,22-25,28,32-33,39H,6-10,12-13,16-17,19,21,26H2,1-5H3,(H,44,45)/t32-,33+,39-/m0/s1
InChi Key	OEQZPFWOEOOISR-AKTKKGGCSA-N
Canonical SMILES	COC1=C(C=C(C=C1)CCC(C2=CC(=CC=C2)OCC(=O)O)OC(=O)C3CCCCN3C(=O)C(C4CCCCC4)C5=CC(=C(C(=C5)OC)OC)OC)OC
Isomeric SMILES	COC1=C(C=C(C=C1)CC[C@H](C2=CC(=CC=C2)OCC(=O)O)OC(=O)[C@@H]3CCCCN3C(=O)[C@@H](C4CCCCC4)C5=CC(=C(C(=C5)OC)OC)OC)OC
PubChem CID	86277875
Molecular Weight	747.87

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Basic Description