Skip to the beginning of the images gallery

SAG - 95%, high purity , CAS No.912545-86-9, Agonist of FZD 6;Agonist of SMO

Moligand™

≥95%

CAS#: 912545-86-9
Formula: C₂₈H₂₈ClN₃OS
Molecular Weight: 490.06
MDL number: MFCD22581513
PubChem CID: 5284330

Item Number

S136512

Grouped product items
SKU	Size	Availability	Price
S136512-1mg	1mg	In stock	$58.90
S136512-5mg	5mg	In stock	$117.90
S136512-10mg	10mg	In stock	$187.90
S136512-25mg	25mg	In stock	$345.90
S136512-50mg	50mg	In stock	$484.90

Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

View related series

FZD6 Agonist SMO Agonist

Basic Description

Synonyms	3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride \| GTPL10327 \| SAG dihydrochloride, >=98% (HPLC) \| BDBM50393851 \| 3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-y
Specifications & Purity	Moligand™, ≥95%
Biochemical and Physiological Mechanisms	Potent Smoothened (Smo) receptor agonist (Kd= 59 nM); antagonizesCyclopamineaction at the Smo receptor. Potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50~ 3 nM). Induces pathway activation independently of Ptch proteins. Putativ
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of FZD 6;Agonist of SMO

Associated Targets(Human)

FZD6 Tbio Frizzled-6 (0 Activities)

Discover Target: FZD6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMO Tclin Smoothened homolog (1 Activities)

Discover Target: SMO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide
INCHI	InChI=1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3
InChi Key	VFSUUTYAEQOIMW-UHFFFAOYSA-N
Canonical SMILES	CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl
Isomeric SMILES	CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl
Alternate CAS	912545-86-9
PubChem CID	5284330
MeSH Entry Terms	SAG 1.1;SAG compound;Smoothened Agonist (SAG)
Molecular Weight	490.06

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
K2216813	Certificate of Analysis	Aug 05, 2024	S136512
K2216814	Certificate of Analysis	Aug 05, 2024	S136512
K2216815	Certificate of Analysis	Aug 05, 2024	S136512
K2216817	Certificate of Analysis	Aug 05, 2024	S136512
K2216818	Certificate of Analysis	Aug 05, 2024	S136512

Solubility

≥24.5 mg/mL in DMSO; ≥16.33 mg/mL in H2O with gentle warming and ultrasonic; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic

Sensitivity

Light sensitive

References

1. Meerang M et al.. (2016) Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma.. Mol Cancer Ther, 15 (5): (1095-105). [PMID:26839306]
2. Yamakawa D et al.. (2022) Cilia-Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury.. Adv Sci (Weinh), 10 (e2202632). [PMID:36373718]
3. Kim BH et al.. (2019) Deficiency of calpain-6 inhibits primary ciliogenesis.. BMB Rep, 52 (10): (619-624). [PMID:31619317]
4. Petsouki E et al.. (2021) FBW7 couples structural integrity with functional output of primary cilia.. Commun Biol, 4 (1066). [PMID:34518642]
5. Xing Y et al.. (2016) Liver X receptor a is essential for the capillarization of liver sinusoidal endothelial cells in liver injury.. Sci Rep, 6 (21309). [PMID:26887957]
6. Tessier S et al.. (2019) NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse\xa0intervertebral disc embryogenesis.. Dev Biol, 455 (2): (369-381). [PMID:31301300]
7. Yamazoe T et al.. (2020) Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling.. J Biol Chem, 295 (43): (14723-14736). [PMID:32820051]
8. Coulter ME et al.. (2018) The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles.. Cell Rep, 24 (4): (973-986.e8). [PMID:30044992]
9. May EA et al.. (2021) Time-resolved proteomics profiling of the ciliary Hedgehog response.. J Cell Biol, 220 (5): [PMID:33856408]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.