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SAGE-718 , CAS No.S613399, Allosteric modulator of GluN2A;Allosteric modulator of GluN2B
Basic Description Synonyms Dalzanemdor | SAGE-718 | Dalzanemdor [INN] | 8ENS5K3JW8 | SAGE718 | UNII-8ENS5K3JW8 | 1629853-48-0 | (25S)-26,26,26-Trifluoro-3alpha-methyl-24-norcholest- 5-ene-3beta,25-diol | (3beta,24S)-25,25,25-Trifluoro-3-methyl-26,27-dinorergost-5-ene-3,24-diol | 26,27-Dinorergost-5- Specifications & Purity Moligand™ Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of GluN2A;Allosteric modulator of GluN2B
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (3S,8S,9S,10R,13R,14S,17R)-3,10,13-trimethyl-17-[(2R,5S)-6,6,6-trifluoro-5-hydroxy-5-methylhexan-2-yl]-1,2,4,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ol INCHI InChI=1S/C27H43F3O2/c1-17(10-13-26(5,32)27(28,29)30)20-8-9-21-19-7-6-18-16-23(2,31)14-15-24(18,3)22(19)11-12-25(20,21)4/h6,17,19-22,31-32H,7-16H2,1-5H3/t17-,19+,20-,21+,22+,23+,24+,25-,26+/m1/s1 InChi Key BVBRUQYHUXKZMQ-JNVAYQLDSA-N Canonical SMILES C[C@H](CC[C@@](C)(C(F)(F)F)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]1[C@H]2CC=C2[C@@]1(CC[C@](C2)(C)O)C)C Isomeric SMILES C[C@H](CC[C@@](C)(C(F)(F)F)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@](C4)(C)O)C)C PubChem CID 86305217
References 1. Hill MD, Blanco MJ, Salituro FG, Bai Z, Beckley JT, Ackley MA, Dai J, Doherty JJ, Harrison BL, Hoffmann EC et al. . (2022) SAGE-718: A First-in-Class N -Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment.. J Med Chem, 71 (13): (1755-70). [PMID:35785990 ] [10.1021/acs.jmedchem.2c00313 ]
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