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Salermide - ≥98%(HPLC), high purity , CAS No.1105698-15-4
SIRT1 and SIRT2 inhibitor
Basic Description Synonyms BDBM50309827 | (E)-N-(3-((2-hydroxynaphthalen-1-yl)methyleneamino)phenyl)-2-phenylpropanamide | SCHEMBL8103931 | EX-A1238 | N-[3-[(2-oxo-1-naphthalenylidene)methylamino]phenyl]-2-phenylpropanamide | N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl] Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours.Salermide is a novel Sirtuin 1 Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description application：
Salermide was used to treat human pulmonary artery smooth muscle cells to study the effect of SIRT1 inhibition on expression of atrogin by qPCR.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-[3-[(2-hydroxynaphthalen-1-yl)methylideneamino]phenyl]-2-phenylpropanamide INCHI InChI=1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30) InChi Key HQSSEGBEYORUBY-UHFFFAOYSA-N Canonical SMILES CC(C1=CC=CC=C1)C(=O)NC2=CC(=CC=C2)N=CC3=C(C=CC4=CC=CC=C43)O Isomeric SMILES CC(C1=CC=CC=C1)C(=O)NC2=CC(=CC=C2)N=CC3=C(C=CC4=CC=CC=C43)O PubChem CID 135659046 Molecular Weight 394.47
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 39.45, Max Conc. mM: 100 Sensitivity Moisture sensitive
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H412: Harmful to aquatic life with long lasting effects
H317: May cause an allergic skin reaction
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P501: Dispose of contents/container to ...
P272: Contaminated work clothing should not be allowed out of the workplace.
P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
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