Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S276603-10mg | 10mg | In stock | $88.90 | |
S276603-50mg | 50mg | In stock | $286.90 | |
S276603-250mg | 250mg | In stock | $1,291.90 | |
S276603-1g | 1g | In stock | $4,649.90 |
Selective, long acting β 2 adrenoceptor agonist
Synonyms | (+-)-4-Hydroxy-alpha(sup 1)-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-m-xylene-alpha,alpha'-diol 1-hydroxy-2-naphthoate (salt) | ADVAIR COMPONENT SALMETEROL XINAFOATE | LIPO-102 COMPONENT SALMETEROL XINAFOATE | Salmeterol xinafoate for system suitability, |
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Specifications & Purity | ≥96% |
Biochemical and Physiological Mechanisms | Selective, long acting β 2 adrenoceptor agonist. Inhibits release of histamine, leukotrienes, prostaglandin D 2 and GM-CSF in concentration-dependent manner. Active in vitro and in vivo . |
Storage Temp | Room temperature,Desiccated |
Shipped In | Normal |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. |
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Pubchem Sid | 488183395 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488183395 |
IUPAC Name | 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol;1-hydroxynaphthalene-2-carboxylic acid |
INCHI | InChI=1S/C25H37NO4.C11H8O3/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21;12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2;1-6,12H,(H,13,14) |
InChi Key | XTZNCVSCVHTPAI-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O.C1=CC=C2C(=C1)C=CC(=C2O)C(=O)O |
Isomeric SMILES | C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O.C1=CC=C2C(=C1)C=CC(=C2O)C(=O)O |
PubChem CID | 56801 |
Molecular Weight | 603.75 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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K2208665 | Certificate of Analysis | Aug 15, 2023 | S276603 |
K2208666 | Certificate of Analysis | Aug 15, 2023 | S276603 |
K2208667 | Certificate of Analysis | Aug 15, 2023 | S276603 |
K2208663 | Certificate of Analysis | Aug 14, 2023 | S276603 |
Solubility | Soluble in ethanol to 25 mM and in DMSO to 100 mM |
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Melt Point(°C) | 137- 138°C |
Pictogram(s) | GHS08, GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H412:Harmful to aquatic life with long lasting effects H318:Causes serious eye damage H370:Causes damage to organs H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P308+P316:IF exposed or concerned: Get emergency medical help immediately. P332+P317:If skin irritation occurs: Get medical help. |
Merck Index | 8337 |
1. Ellis KE et al.. (1995) Correlation of cyclic AMP accumulation and relaxant actions of salmeterol and salbutamol in bovine tracheal smooth muscle.. Br J Pharmacol, 116 (5): (2510-6). [PMID:8581292] |
2. Coleman RA. (2009) On the mechanism of the persistent action of salmeterol: what is the current position?. Br J Pharmacol, 158 (180-2). [PMID:19719780] |
3. Johnson M et al.. (1993) The pharmacology of salmeterol.. Life Sci, 52 (26): (2131-43). [PMID:8099695] |