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Sangivamycin - ≥98%, high purity , CAS No.18417-89-5

≥98%

CAS#: 18417-89-5
Formula: C₁₂H₁₅N₅O₅
Molecular Weight: 309.28
PubChem CID: 14978

Item Number

S339041

Grouped product items
SKU	Size	Availability	Price
S339041-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$59.90
S339041-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$179.90
S339041-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$289.90
S339041-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$579.90
S339041-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$929.90
S339041-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,499.90

a cytotoxic purine nucleoside

View related series

Nucleoside Antimetabolite/Analog

Basic Description

Synonyms	sangivamycin\|18417-89-5\|7-Deazaadenosine-7-carboxamide\|L8YQ8Z3T9T\|7-Deaza-7-carbamoyladenosine\|Antibiotic B-14437\|CHEMBL101892\|CHEBI:85997\|NSC-65346\|4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Sangivamycin is a cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). Sangivamycin is also a selective and potent PKC (protein kinase C) inhibitor (IC\|50\|= 10μM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors. The phosphorylation of histone H1 protein is a mechanism by which Sangivamycin prevents the cell growth and acts as cytotoxic agent against a variety of human cancers. Product description Sangivamycin, a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers.

Associated Targets

DOT1L Tchem Histone-lysine N-methyltransferase, H3 lysine-79 specific 0 Activities

Discover Target: DOT1L

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRK1 Tchem Rhodopsin kinase 0 Activities

Discover Target: GRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSPA8 Tchem Heat shock cognate 71 kDa protein 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JUN Tchem Transcription factor AP-1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK8 Tchem Mitogen-activated protein kinase 8 0 Activities

Discover Target: MAPK8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BCL2L1 Tchem Bcl-2-like protein 1 0 Activities

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ADK Tchem Adenosine kinase 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRK2 Tchem Beta-adrenergic receptor kinase 1 0 Activities

Discover Target: GRK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide
INCHI	InChI=1S/C12H15N5O5/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16)/t5-,7-,8-,12-/m1/s1
InChi Key	OBZJZDHRXBKKTJ-JTFADIMSSA-N
Canonical SMILES	C1=C(C2=C(N=CN=C2N1C3C(C(C(O3)CO)O)O)N)C(=O)N
Isomeric SMILES	C1=C(C2=C(N=CN=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)C(=O)N
WGK Germany	3
RTECS	UY9355000
PubChem CID	14978
Molecular Weight	309.28

Solubility

Soluble in cold water, and 0.1 M KOH.

Refractive Index

n20D1.89 (Predicted)

Boil Point(°C)

880.6° C at 760 mmHg (Predicted)

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H300:Fatal if swallowed H310:Fatal in contact with skin H330:Fatal if inhaled
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P262:Do not get in eyes, on skin, or on clothing. P320:Specific treatment is urgent (see ... on this label). P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately.
WGK Germany	3
RTECS	UY9355000

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