Sanguinarine chloride hydrate - ≥97% (HPLC), high purity , CAS No.5578-73-4

Item Number

S101540

• Synonyms: SANGUINARINE CHLORIDE | FD10130 | Q-100647 | (1,3)Benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium, 13-methyl-, chloride | LS-14752 | 5578-73-4 (chloride) | D05799 | CS-4784 | NCGC00094379-01 | SANGUINARINECHLORIDE | Sanguinarium chloride (USAN/INN)
• Specifications & Purity: ≥97%(HPLC)
• Biochemical and Physiological Mechanisms: Selective PP2C inhibitor. Inhibits MKP-1 (IC 50 = 10 μM). Induces cell cycle arrest in the G 1 phase. Induces ROS-mediated oxidative stress in growing cells. Shows antiproliferative and cytotoxic effects (IC 50 = 7.6 μM for S-G gingival epithelial cells).
• Shipped In: Normal
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Sanguinarine chloride is a benzophenanthridine alkaloid and potent, noncompetitive sodium/Potassium-ATPase Protein Inhibitors (Na+/K+ ATPase) inhibitor with anticancer properties. This product has been observed to induce apoptosis in cultured C6 rat glioblastoma cells potentially via a downregulative ability of extracellular singal-regulated and Akt signaling pathways. It is reported that sanguinarine also inhibits protein phosphatase 2C (PP2) and induces human promyelocytic leukemia cell line HL60 apoptosis through the phosphorylation of p38, a PP2Cα substrate associated with caspase-3/7 activity. This compound posesses antimicrobial and anti-plaque qualities. Sanguinarine chloride is an inhibitor of MKP-1 and PP2. Isolated from the leaves and stems of Macleaya cordata and M. microcarpa.
A benzophenanthridine alkaloid and potent, noncompetitive Na+/K+-and Mg2++-ATPase inhibitor