Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
S275667-1mg | 1mg | In stock | $23.90 | |
S275667-5mg | 5mg | In stock | $79.90 | |
S275667-25mg | 25mg | In stock | $266.90 | |
S275667-100mg | 100mg | In stock | $733.90 |
Potent smoothened receptor antagonist
Synonyms | GTPL10331 | J-018936 | HY-107408 | SR-01000419345 | NCGC00263210-04 | BDBM50249489 | HMS3414C13 | NCGC00263210-06 | SR-01000419345-1 | HMS3678C13 | N-(3-(1H-Benzimidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide | N-(3-(1H-benzo[d]imidazol-2-yl)-4-ch |
---|---|
Specifications & Purity | Moligand™, ≥95% |
Biochemical and Physiological Mechanisms | Potent smoothened receptor antagonist. Allosteric modulation similar to SANT-1. Able to displace smo- [ 3 H]SAG-1.3 and [ 3 H]Cyclopamine binding (K i values are 7.8 and 8.4 nM respectively). |
Storage Temp | Protected from light,Store at -20°C,Argon charged,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of SMO |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
---|
IUPAC Name | N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide |
---|---|
INCHI | InChI=1S/C26H26ClN3O4/c1-4-32-22-13-16(14-23(33-5-2)24(22)34-6-3)26(31)28-17-11-12-19(27)18(15-17)25-29-20-9-7-8-10-21(20)30-25/h7-15H,4-6H2,1-3H3,(H,28,31)(H,29,30) |
InChi Key | VQOJFGFKIVFMDH-UHFFFAOYSA-N |
Canonical SMILES | CCOC1=CC(=CC(=C1OCC)OCC)C(=O)NC2=CC(=C(C=C2)Cl)C3=NC4=CC=CC=C4N3 |
Isomeric SMILES | CCOC1=CC(=CC(=C1OCC)OCC)C(=O)NC2=CC(=C(C=C2)Cl)C3=NC4=CC=CC=C4N3 |
Alternate CAS | 329196-48-7 |
PubChem CID | 1367095 |
Molecular Weight | 479.96 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
B23271024 | Certificate of Analysis | Jan 03, 2023 | S275667 |
B23271034 | Certificate of Analysis | Jan 03, 2023 | S275667 |
B23271035 | Certificate of Analysis | Jan 03, 2023 | S275667 |
B23271096 | Certificate of Analysis | Jan 03, 2023 | S275667 |
Solubility | Soluble in DMSO to 100 mM and in ethanol to 100 mM |
---|---|
Sensitivity | Air sensitive,Light sensitive,Heat sensitive |