SANT-2 - ≥95%, high purity , CAS No.329196-48-7, Antagonist of SMO

Item Number
S275667
Grouped product items
SKUSizeAvailabilityPrice Qty
S275667-1mg
1mg
In stock
$23.90
S275667-5mg
5mg
In stock
$79.90
S275667-25mg
25mg
In stock
$266.90
S275667-100mg
100mg
In stock
$733.90

Potent smoothened receptor antagonist

View related series
SMO Antagonist

Basic Description

SynonymsGTPL10331 | J-018936 | HY-107408 | SR-01000419345 | NCGC00263210-04 | BDBM50249489 | HMS3414C13 | NCGC00263210-06 | SR-01000419345-1 | HMS3678C13 | N-(3-(1H-Benzimidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide | N-(3-(1H-benzo[d]imidazol-2-yl)-4-ch
Specifications & PurityMoligand™, ≥95%
Biochemical and Physiological MechanismsPotent smoothened receptor antagonist. Allosteric modulation similar to SANT-1. Able to displace smo- [ 3 H]SAG-1.3 and [ 3 H]Cyclopamine binding (K i values are 7.8 and 8.4 nM respectively).
Storage TempProtected from light,Store at -20°C,Argon charged,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of SMO
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

SMO Tclin Smoothened homolog (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Shh Sonic hedgehog protein (356 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Oryzias latipes (115 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
INCHI InChI=1S/C26H26ClN3O4/c1-4-32-22-13-16(14-23(33-5-2)24(22)34-6-3)26(31)28-17-11-12-19(27)18(15-17)25-29-20-9-7-8-10-21(20)30-25/h7-15H,4-6H2,1-3H3,(H,28,31)(H,29,30)
InChi Key VQOJFGFKIVFMDH-UHFFFAOYSA-N
Canonical SMILES CCOC1=CC(=CC(=C1OCC)OCC)C(=O)NC2=CC(=C(C=C2)Cl)C3=NC4=CC=CC=C4N3
Isomeric SMILES CCOC1=CC(=CC(=C1OCC)OCC)C(=O)NC2=CC(=C(C=C2)Cl)C3=NC4=CC=CC=C4N3
Alternate CAS 329196-48-7
PubChem CID 1367095
Molecular Weight 479.96

Certificates

Certificate of Analysis(COA)

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4 results found

Lot NumberCertificate TypeDateItem
B23271024Certificate of AnalysisJan 03, 2023 S275667
B23271034Certificate of AnalysisJan 03, 2023 S275667
B23271035Certificate of AnalysisJan 03, 2023 S275667
B23271096Certificate of AnalysisJan 03, 2023 S275667

Chemical and Physical Properties

SolubilitySoluble in DMSO to 100 mM and in ethanol to 100 mM
SensitivityAir sensitive,Light sensitive,Heat sensitive

Related Documents

Solution Calculators