Basic Description

Synonyms	santacruzamate A\|1477949-42-0\|CAY10683\|Santacruzamate A (CAY10683)\|CAY10683 (SantacruzaMate A)\|ethyl N-[4-oxo-4-(2-phenylethylamino)butyl]carbamate\|Ethyl (4-oxo-4-(phenethylamino)butyl)carbamate\|CAY10683(Santacruzamate A)\|CHEMBL3086767\|Carbamic acid, N-[4
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Highly potent and selective histone deactylase 2 (HDAC2) inhibitor (IC50= 112 - 119 pM). Also inhibits HDAC6 in nanomolar range (IC50= 433 nM). Displays >3500 fold selectivity for HDAC2 over HDAC6, and >8500-fold selectivity over HDAC4 (IC50>1 μM for HDAC
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 6

Associated Targets

DNMT3A Tclin DNA (cytosine-5)-methyltransferase 3A 0 Activities

Discover Target: DNMT3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DNMT3B Tchem DNA (cytosine-5)-methyltransferase 3B 0 Activities

Discover Target: DNMT3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 0 Activities

Discover Target: DNMT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC4 Tclin Histone deacetylase 4 1 Activities

Discover Target: HDAC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 3 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC1 Tclin Histone deacetylase 1 0 Activities

Discover Target: HDAC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC7 Tclin Histone deacetylase 7 0 Activities

Discover Target: HDAC7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC11 Tclin Histone deacetylase 11 0 Activities

Discover Target: HDAC11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC9 Tclin Histone deacetylase 9 0 Activities

Discover Target: HDAC9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC2 Tclin Histone deacetylase 2 3 Activities

Discover Target: HDAC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIRT5 Tchem NAD-dependent protein deacylase sirtuin-5, mitochondrial 0 Activities

Discover Target: SIRT5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIRT3 Tchem NAD-dependent protein deacetylase sirtuin-3, mitochondrial 0 Activities

Discover Target: SIRT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIRT2 Tchem NAD-dependent protein deacetylase sirtuin-2 0 Activities

Discover Target: SIRT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIRT1 Tchem NAD-dependent protein deacetylase sirtuin-1 0 Activities

Discover Target: SIRT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC10 Tclin Histone deacetylase 10 0 Activities

Discover Target: HDAC10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC8 Tclin Histone deacetylase 8 0 Activities

Discover Target: HDAC8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC5 Tclin Histone deacetylase 5 0 Activities

Discover Target: HDAC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC3 Tclin Histone deacetylase 3 0 Activities

Discover Target: HDAC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	ethyl N-[4-oxo-4-(2-phenylethylamino)butyl]carbamate
INCHI	InChI=1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19)
InChi Key	HTOYBIILVCHURC-UHFFFAOYSA-N
Canonical SMILES	CCOC(=O)NCCCC(=O)NCCC1=CC=CC=C1
Isomeric SMILES	CCOC(=O)NCCCC(=O)NCCC1=CC=CC=C1
PubChem CID	72946782
Molecular Weight	278.35

Database links

CAS Registry No.	1477949-42-0
ChEMBL Ligand	CHEMBL3086767
PubChem CID	72946782

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
I2216327	Certificate of Analysis	Jul 04, 2022	S288868
I2216415	Certificate of Analysis	Jul 04, 2022	S288868
I2216648	Certificate of Analysis	Jul 04, 2022	S288868

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 27.84, Max Conc. mM: 100

References

1. Pavlik CM, Wong CY, Ononye S, Lopez DD, Engene N, McPhail KL, Gerwick WH, Balunas MJ. (2013) Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.. J Nat Prod, 76 (11): (2026-33). [PMID:24164245]

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SKU	Size	Availability	Price
S288868-10mg	10mg	In stock	$63.90
S288868-50mg	50mg	In stock	$246.90
S288868-100mg	100mg	In stock	$370.90

Santacruzamate A - ≥98%(HPLC), high purity , CAS No.1477949-42-0, Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 6