SAR-20347 - 97%, high purity , CAS No.1450881-55-6, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2

Item Number

S412384

• Synonyms: 2-(2-Chloro-6-fluorophenyl)-5-(4-(morpholine-4-carbonyl)phenylamino)oxazole-4-carboxamide | SAR20347 | SAR 20347 | 2-(2-Chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-4-oxazolecarboxamide
• Specifications & Purity: Moligand™, ≥97%
• Biochemical and Physiological Mechanisms: SAR-20347 is a potent inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50 of 0.6 nM, 23 nM, 26 nM and 41 nM, respectively. SAR-20347 inhibits TYK2- and JAK1-mediated IL-12 and IFN-α signaling.
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2

Product Description

Information

SAR-20347 is a potent inhibitor ofTYK2,JAK1,JAK2andJAK3with IC50 of 0.6 nM, 23 nM, 26 nM and 41 nM, respectively. SAR-20347 inhibits TYK2- and JAK1-mediatedIL-12andIFN-αsignaling.

Targets

IL-12 ; IFN-α ; TYK2 (Cell-free assay); JAK1 (Cell-free assay); JAK2 (Cell-free assay) 32707,; 0.6 nM; 23 nM; 26 nM