Sar-[D-Phe8]-des-Arg9-Bradykinin TFA salt, CAS No.126959-88-4(free base), Agonist of B 1 receptor

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    Item Number
    S287120
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    S287120-1mg
    1mg
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    $129.90
    S287120-5mg
    5mg
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    $419.90
    S287120-10mg
    10mg
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    S287120-25mg
    25mg
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    S287120-50mg
    50mg
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    $1,999.90

    Potent and selective B1agonist

    View related series
    B1 receptor Agonist

    Basic Description

    Product NameSar-[D-Phe8]-des-Arg9-Bradykinin TFA salt, CAS No.126959-88-4(free base)
    GradeMoligand™
    Specifications & PurityMoligand™, ≥98%
    Biochemical and Physiological MechanismsPotent and selective bradykinin B1receptor agonist (EC50= 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activityin vivo.
    SequenceXRPPGFSPF(Modifications: X = Sar, Phe-9 = D-Phe)
    Action TypeAGONIST
    Mechanism of actionAgonist of B 1 receptor

    Associated Targets(Human)

    BDKRB1 Tchem B1 bradykinin receptor (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    Storage TempStore at -20°C,Desiccated
    Shipped InIce chest + Ice pads
    CAS126959-88-4(free base)

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    10 results found

    Lot NumberCertificate TypeDateItem
    B2418551Certificate of AnalysisJan 03, 2024 S287120
    B2418552Certificate of AnalysisJan 03, 2024 S287120
    B2418553Certificate of AnalysisJan 03, 2024 S287120
    B2418554Certificate of AnalysisJan 03, 2024 S287120
    B2418555Certificate of AnalysisJan 03, 2024 S287120
    B2418556Certificate of AnalysisJan 03, 2024 S287120
    B2418557Certificate of AnalysisJan 03, 2024 S287120
    B2418558Certificate of AnalysisJan 03, 2024 S287120
    B2418568Certificate of AnalysisJan 03, 2024 S287120
    B2418631Certificate of AnalysisJan 03, 2024 S287120

    Genetic information

    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Drapeau G, deBlois D, Marceau F.  (1991)  Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kinins..  J Pharmacol Exp Ther,  259  (3): (997-1003).  [PMID:1662280] [10.1021/op500134e]
    2. Audet R, Rioux F, Drapeau G, Marceau F.  (1997)  Cardiovascular effects of Sar-[D-Phe8]des-Arg9-bradykinin, a metabolically protected agonist of B1 receptor for kinins, in the anesthetized rabbit pretreated with a sublethal dose of bacterial lipopolysaccharide..  J Pharmacol Exp Ther,  280  (1): (6-15).  [PMID:8996175] [10.1021/op500134e]

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