SAR7334 - 97%, high purity , CAS No.1333210-07-3, Channel blocker of TRPC3;Channel blocker of TRPC6;Channel blocker of TRPC7

Item Number
S413561
Grouped product items
SKUSizeAvailabilityPrice Qty
S413561-5mg
5mg
In stock
$197.90
S413561-10mg
10mg
In stock
$315.90
S413561-25mg
25mg
In stock
$459.90
S413561-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$711.90
S413561-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$890.90

TRP Channel Inhibitors

Basic Description

Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsSAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeCHANNEL BLOCKER
Mechanism of actionChannel blocker of TRPC3;Channel blocker of TRPC6;Channel blocker of TRPC7
Product Description

Information

SAR7334 SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment.


Targets

TPRC6 (Cell-free assay) 7.9nM


In vitro

SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected..SAR7334 suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice.


In vivo

Pharmacokinetic studies of SAR7334 demonstrates that the compound was suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).


Cell Research(from reference)

Cell lines:HEK cells 

Product Properties

ALogP3.871
HBD Count1
Rotatable Bond3

Associated Targets(Human)

TRPC3 Tchem Short transient receptor potential channel 3 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TRPC6 Tchem Short transient receptor potential channel 6 (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TRPC7 Tchem Short transient receptor potential channel 7 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TRPC5 Tchem Short transient receptor potential channel 5 (300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TRPC3 Tchem Short transient receptor potential channel 3 (70 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TRPC7 Tchem Short transient receptor potential channel 7 (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trpc4 Short transient receptor potential channel 4 (1615 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trpc6 Short transient receptor potential channel 6 (57 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 4-[[(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile
INCHI InChI=1S/C21H22ClN3O/c22-18-10-14(12-23)7-8-20(18)26-21-17-6-2-1-4-15(17)11-19(21)25-9-3-5-16(24)13-25/h1-2,4,6-8,10,16,19,21H,3,5,9,11,13,24H2/t16-,19-,21-/m1/s1
InChi Key RLKRLNQEXBPQGQ-OZOXKJRCSA-N
Canonical SMILES C1CC(CN(C1)C2CC3=CC=CC=C3C2OC4=C(C=C(C=C4)C#N)Cl)N
Isomeric SMILES C1C[C@H](CN(C1)[C@@H]2CC3=CC=CC=C3[C@H]2OC4=C(C=C(C=C4)C#N)Cl)N
PubChem CID 53378752
Molecular Weight 367.87

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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3 results found

Lot NumberCertificate TypeDateItem
H2222150Certificate of AnalysisJun 28, 2022 S413561
H2222151Certificate of AnalysisJun 28, 2022 S413561
H2222158Certificate of AnalysisJun 28, 2022 S413561

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 74 mg/mL (201.15 mM); Ethanol: 74 mg/mL (201.15 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility74
DMSO(mM) Max Solubility201.158017778019
Water(mg / mL) Max Solubility<1

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

Related Documents

References

1. Maier T, Follmann M, Hessler G, Kleemann HW, Hachtel S, Fuchs B, Weissmann N, Linz W, Schmidt T, Löhn M et al..  (2015)  Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels..  Br J Pharmacol,  172  (14): (3650-60).  [PMID:25847402] [10.1021/op500134e]

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