Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase ( SAMDC ) inhibitor with an IC 50 of 5 nM.
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Product Description
Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase ( SAMDC ) inhibitor with an IC 50 of 5 nM.
In Vitro
Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC 50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Assay
The parent CHO cell line is chronically exposed to increasing levels of Sardomozide for at least eight passages beginning at 0.1 μM . Cell lines are serially exposed to increasing concentrations until a panel of sublines is obtained resistant to 1 (CHO/1). 3 (CHO/3), 10 (CHO/10), 30 (CHO/30), and 100 (CHO/100) μM Sardomozide for comparative studies. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
